White KL - Search Results

1

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.

Lansdon EB, Samuel D, Lagpacan L, Brendza KM, White KL, Hung M, Liu X, Boojamra CG, Mackman RL, Cihlar T, Ray AS, McGrath ME, Swaminathan S. Lansdon EB, et al. Among authors: white kl. J Mol Biol. 2010 Apr 9;397(4):967-78. doi: 10.1016/j.jmb.2010.02.019. Epub 2010 Feb 13. J Mol Biol. 2010. PMID: 20156454

2

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity.

White KL, Margot NA, Wrin T, Petropoulos CJ, Miller MD, Naeger LK. White KL, et al. Antimicrob Agents Chemother. 2002 Nov;46(11):3437-46. doi: 10.1128/AAC.46.11.3437-3446.2002. Antimicrob Agents Chemother. 2002. PMID: 12384348 Free PMC article.

3

Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations.

White KL, Chen JM, Margot NA, Wrin T, Petropoulos CJ, Naeger LK, Swaminathan S, Miller MD. White KL, et al. Antimicrob Agents Chemother. 2004 Mar;48(3):992-1003. doi: 10.1128/AAC.48.3.992-1003.2004. Antimicrob Agents Chemother. 2004. PMID: 14982794 Free PMC article.

4

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.

Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E. Tuske S, et al. Among authors: white kl. Nat Struct Mol Biol. 2004 May;11(5):469-74. doi: 10.1038/nsmb760. Epub 2004 Apr 25. Nat Struct Mol Biol. 2004. PMID: 15107837

5

A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

White KL, Margot NA, Ly JK, Chen JM, Ray AS, Pavelko M, Wang R, McDermott M, Swaminathan S, Miller MD. White KL, et al. AIDS. 2005 Nov 4;19(16):1751-60. doi: 10.1097/01.aids.0000189851.21441.f1. AIDS. 2005. PMID: 16227782

6

The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.

White KL, Chen JM, Feng JY, Margot NA, Ly JK, Ray AS, Macarthur HL, McDermott MJ, Swaminathan S, Miller MD. White KL, et al. Antivir Ther. 2006;11(2):155-63. doi: 10.1177/135965350601100209. Antivir Ther. 2006. PMID: 16640096

7

Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Cihlar T, Ray AS, Boojamra CG, Zhang L, Hui H, Laflamme G, Vela JE, Grant D, Chen J, Myrick F, White KL, Gao Y, Lin KY, Douglas JL, Parkin NT, Carey A, Pakdaman R, Mackman RL. Cihlar T, et al. Among authors: white kl. Antimicrob Agents Chemother. 2008 Feb;52(2):655-65. doi: 10.1128/AAC.01215-07. Epub 2007 Dec 3. Antimicrob Agents Chemother. 2008. PMID: 18056282 Free PMC article.

8

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

Ly JK, Margot NA, MacArthur HL, Hung M, Miller MD, White KL. Ly JK, et al. Among authors: white kl. Antivir Chem Chemother. 2007;18(6):307-16. doi: 10.1177/095632020701800603. Antivir Chem Chemother. 2007. PMID: 18320935 Free article.

9

The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.

Svarovskaia ES, Feng JY, Margot NA, Myrick F, Goodman D, Ly JK, White KL, Kutty N, Wang R, Borroto-Esoda K, Miller MD. Svarovskaia ES, et al. Among authors: white kl. J Acquir Immune Defic Syndr. 2008 Aug 1;48(4):428-36. doi: 10.1097/QAI.0b013e31817bbe93. J Acquir Immune Defic Syndr. 2008. PMID: 18614922

10

Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.

Waters JM, O'Neal W, White KL, Wakeford C, Lansdon EB, Harris J, Svarovskaia ES, Miller MD, Borroto-Esoda K. Waters JM, et al. Among authors: white kl. Antivir Ther. 2009;14(2):231-9. Antivir Ther. 2009. PMID: 19430098

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