Fernandez A - Search Results

1

c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer.

Vivas-Mejia P, Benito JM, Fernandez A, Han HD, Mangala L, Rodriguez-Aguayo C, Chavez-Reyes A, Lin YG, Carey MS, Nick AM, Stone RL, Kim HS, Claret FX, Bornmann W, Hennessy BT, Sanguino A, Peng Z, Sood AK, Lopez-Berestein G. Vivas-Mejia P, et al. Among authors: fernandez a. Clin Cancer Res. 2010 Jan 1;16(1):184-94. doi: 10.1158/1078-0432.CCR-09-1180. Epub 2009 Dec 22. Clin Cancer Res. 2010. PMID: 20028751 Free PMC article.

2

Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma.

Halder J, Lin YG, Merritt WM, Spannuth WA, Nick AM, Honda T, Kamat AA, Han LY, Kim TJ, Lu C, Tari AM, Bornmann W, Fernandez A, Lopez-Berestein G, Sood AK. Halder J, et al. Among authors: fernandez a. Cancer Res. 2007 Nov 15;67(22):10976-83. doi: 10.1158/0008-5472.CAN-07-2667. Cancer Res. 2007. PMID: 18006843

3

An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic.

Fernández A, Sanguino A, Peng Z, Ozturk E, Chen J, Crespo A, Wulf S, Shavrin A, Qin C, Ma J, Trent J, Lin Y, Han HD, Mangala LS, Bankson JA, Gelovani J, Samarel A, Bornmann W, Sood AK, Lopez-Berestein G. Fernández A, et al. J Clin Invest. 2007 Dec;117(12):4044-54. doi: 10.1172/JCI32373. J Clin Invest. 2007. PMID: 18060038 Free PMC article.

4

Rational drug redesign to overcome drug resistance in cancer therapy: imatinib moving target.

Fernández A, Sanguino A, Peng Z, Crespo A, Ozturk E, Zhang X, Wang S, Bornmann W, Lopez-Berestein G. Fernández A, et al. Cancer Res. 2007 May 1;67(9):4028-33. doi: 10.1158/0008-5472.CAN-07-0345. Cancer Res. 2007. PMID: 17483313 Free PMC article.

5

Induced disorder in protein-ligand complexes as a drug-design strategy.

Crespo A, Fernández A. Crespo A, et al. Among authors: fernandez a. Mol Pharm. 2008 May-Jun;5(3):430-7. doi: 10.1021/mp700148h. Epub 2008 Feb 16. Mol Pharm. 2008. PMID: 18278867

6

Redesigning kinase inhibitors to enhance specificity.

Crespo A, Zhang X, Fernández A. Crespo A, et al. Among authors: fernandez a. J Med Chem. 2008 Aug 28;51(16):4890-8. doi: 10.1021/jm800453a. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680272

7

Kinase packing defects as drug targets.

Crespo A, Fernández A. Crespo A, et al. Among authors: fernandez a. Drug Discov Today. 2007 Nov;12(21-22):917-23. doi: 10.1016/j.drudis.2007.09.009. Epub 2007 Oct 30. Drug Discov Today. 2007. PMID: 17993409 Free PMC article. Review.

8

Incomplete protein packing as a selectivity filter in drug design.

Fernández A. Fernández A. Structure. 2005 Dec;13(12):1829-36. doi: 10.1016/j.str.2005.08.018. Structure. 2005. PMID: 16338411 Free PMC article.

9

Turning promiscuous kinase inhibitors into safer drugs.

Zhang X, Crespo A, Fernández A. Zhang X, et al. Among authors: fernandez a. Trends Biotechnol. 2008 Jun;26(6):295-301. doi: 10.1016/j.tibtech.2008.02.008. Epub 2008 Apr 9. Trends Biotechnol. 2008. PMID: 18403035 Review.

10

Selective antagonism of anticancer drugs for side-effect removal.

Fernández A, Sessel S. Fernández A, et al. Trends Pharmacol Sci. 2009 Aug;30(8):403-10. doi: 10.1016/j.tips.2009.06.001. Trends Pharmacol Sci. 2009. PMID: 19595465

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