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3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Gurrieri C, Piazza F, Gnoato M, Montini B, Biasutto L, Gattazzo C, Brunetta E, Cabrelle A, Cinetto F, Niero R, Facco M, Garbisa S, Calabrese F, Semenzato G, Agostini C. Gurrieri C, et al. Among authors: cabrelle a. J Pharmacol Exp Ther. 2010 Mar;332(3):785-94. doi: 10.1124/jpet.109.153049. Epub 2009 Dec 3. J Pharmacol Exp Ther. 2010. PMID: 19959748
Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Dell'Aica I, Niero R, Piazza F, Cabrelle A, Sartor L, Colalto C, Brunetta E, Lorusso G, Benelli R, Albini A, Calabrese F, Agostini C, Garbisa S. Dell'Aica I, et al. Among authors: cabrelle a. J Pharmacol Exp Ther. 2007 May;321(2):492-500. doi: 10.1124/jpet.106.116459. Epub 2007 Feb 8. J Pharmacol Exp Ther. 2007. PMID: 17289834 Free article.
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C. Facco M, et al. Among authors: cabrelle a. J Leukoc Biol. 2007 Oct;82(4):946-55. doi: 10.1189/jlb.0307133. Epub 2007 Jul 5. J Leukoc Biol. 2007. PMID: 17615381
Sarcoidosis is a Th1/Th17 multisystem disorder.
Facco M, Cabrelle A, Teramo A, Olivieri V, Gnoato M, Teolato S, Ave E, Gattazzo C, Fadini GP, Calabrese F, Semenzato G, Agostini C. Facco M, et al. Among authors: cabrelle a. Thorax. 2011 Feb;66(2):144-50. doi: 10.1136/thx.2010.140319. Epub 2010 Dec 7. Thorax. 2011. PMID: 21139119
CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis.
Agostini C, Calabrese F, Poletti V, Marcer G, Facco M, Miorin M, Cabrelle A, Baesso I, Zambello R, Trentin L, Semenzato G. Agostini C, et al. Among authors: cabrelle a. Respir Res. 2005 Feb 22;6(1):20. doi: 10.1186/1465-9921-6-20. Respir Res. 2005. PMID: 15725351 Free PMC article. Clinical Trial.
Multiple myeloma cell survival relies on high activity of protein kinase CK2.
Piazza FA, Ruzzene M, Gurrieri C, Montini B, Bonanni L, Chioetto G, Di Maira G, Barbon F, Cabrelle A, Zambello R, Adami F, Trentin L, Pinna LA, Semenzato G. Piazza FA, et al. Among authors: cabrelle a. Blood. 2006 Sep 1;108(5):1698-707. doi: 10.1182/blood-2005-11-013672. Epub 2006 May 9. Blood. 2006. PMID: 16684960 Free article.
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.
Manni S, Brancalion A, Tubi LQ, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, Ruzzene M, Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F. Manni S, et al. Among authors: cabrelle a. Clin Cancer Res. 2012 Apr 1;18(7):1888-900. doi: 10.1158/1078-0432.CCR-11-1789. Epub 2012 Feb 20. Clin Cancer Res. 2012. PMID: 22351691
59 results