A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis.
He W, Brumos J, Li H, Ji Y, Ke M, Gong X, Zeng Q, Li W, Zhang X, An F, Wen X, Li P, Chu J, Sun X, Yan C, Yan N, Xie DY, Raikhel N, Yang Z, Stepanova AN, Alonso JM, Guo H.
He W, et al. Among authors: an f.
Plant Cell. 2011 Nov;23(11):3944-60. doi: 10.1105/tpc.111.089029. Epub 2011 Nov 22.
Plant Cell. 2011.
PMID: 22108404
Free PMC article.
Further biochemical and phenotypic analyses revealed that Kyn, being an alternate substrate, competitively inhibits TAA1/TAR activity, and Kyn treatment mimicked the loss of TAA1/TAR functions. ...To elucidate the destabilizing effect of Kyn on EIN3, we further found that …
Further biochemical and phenotypic analyses revealed that Kyn, being an alternate substrate, competitively inhibits TAA1/TAR activity …