Dunn TM - Search Results

1

Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1.

Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH Jr. Eichler FS, et al. Among authors: dunn tm. J Neurosci. 2009 Nov 18;29(46):14646-51. doi: 10.1523/JNEUROSCI.2536-09.2009. J Neurosci. 2009. PMID: 19923297 Free PMC article.

2

Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.

Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM. Gable K, et al. Among authors: dunn tm. J Biol Chem. 2002 Mar 22;277(12):10194-200. doi: 10.1074/jbc.M107873200. Epub 2002 Jan 7. J Biol Chem. 2002. PMID: 11781309 Free article.

3

Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae.

Monaghan E, Gable K, Dunn T. Monaghan E, et al. Yeast. 2002 Jun 15;19(8):659-70. doi: 10.1002/yea.864. Yeast. 2002. PMID: 12185836

4

The topology of the Lcb1p subunit of yeast serine palmitoyltransferase.

Han G, Gable K, Yan L, Natarajan M, Krishnamurthy J, Gupta SD, Borovitskaya A, Harmon JM, Dunn TM. Han G, et al. Among authors: dunn tm. J Biol Chem. 2004 Dec 17;279(51):53707-16. doi: 10.1074/jbc.M410014200. Epub 2004 Oct 12. J Biol Chem. 2004. PMID: 15485854 Free article.

5

Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.

McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH Jr. McCampbell A, et al. Among authors: dunn tm. Hum Mol Genet. 2005 Nov 15;14(22):3507-21. doi: 10.1093/hmg/ddi380. Epub 2005 Oct 6. Hum Mol Genet. 2005. PMID: 16210380

6

Expression of a novel marine viral single-chain serine palmitoyltransferase and construction of yeast and mammalian single-chain chimera.

Han G, Gable K, Yan L, Allen MJ, Wilson WH, Moitra P, Harmon JM, Dunn TM. Han G, et al. Among authors: dunn tm. J Biol Chem. 2006 Dec 29;281(52):39935-42. doi: 10.1074/jbc.M609365200. Epub 2006 Nov 6. J Biol Chem. 2006. PMID: 17090526 Free article.

7

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities.

Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F, Brown RH Jr, Harmon JM, Dunn TM. Han G, et al. Among authors: dunn tm. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8186-91. doi: 10.1073/pnas.0811269106. Epub 2009 May 5. Proc Natl Acad Sci U S A. 2009. PMID: 19416851 Free PMC article.

8

A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity.

Gable K, Gupta SD, Han G, Niranjanakumari S, Harmon JM, Dunn TM. Gable K, et al. Among authors: dunn tm. J Biol Chem. 2010 Jul 23;285(30):22846-52. doi: 10.1074/jbc.M110.122259. Epub 2010 May 26. J Biol Chem. 2010. PMID: 20504773 Free PMC article.

9

Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferase.

Harmon JM, Bacikova D, Gable K, Gupta SD, Han G, Sengupta N, Somashekarappa N, Dunn TM. Harmon JM, et al. Among authors: dunn tm. J Biol Chem. 2013 Apr 5;288(14):10144-10153. doi: 10.1074/jbc.M113.451526. Epub 2013 Feb 20. J Biol Chem. 2013. PMID: 23426370 Free PMC article.

10

The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations.

Beattie AE, Gupta SD, Frankova L, Kazlauskaite A, Harmon JM, Dunn TM, Campopiano DJ. Beattie AE, et al. Among authors: dunn tm. Biomed Res Int. 2013;2013:194371. doi: 10.1155/2013/194371. Epub 2013 Sep 23. Biomed Res Int. 2013. PMID: 24175284 Free PMC article.

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