Carfì A - Search Results

1

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A. Ontoria JM, et al. Among authors: carfi a. J Med Chem. 2009 Aug 27;52(16):5217-27. doi: 10.1021/jm900517t. J Med Chem. 2009. PMID: 19877603

2

Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

De Francesco R, Carfí A. De Francesco R, et al. Among authors: carfi a. Adv Drug Deliv Rev. 2007 Oct 10;59(12):1242-62. doi: 10.1016/j.addr.2007.04.016. Epub 2007 Aug 11. Adv Drug Deliv Rev. 2007. PMID: 17869377 Review.

3

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.

Jones P, Bottomley MJ, Carfí A, Cecchetti O, Ferrigno F, Lo Surdo P, Ontoria JM, Rowley M, Scarpelli R, Schultz-Fademrecht C, Steinkühler C. Jones P, et al. Among authors: carfi a. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3456-61. doi: 10.1016/j.bmcl.2008.02.026. Epub 2008 Feb 14. Bioorg Med Chem Lett. 2008. PMID: 18440229

4

Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.

Rydberg EH, Cellucci A, Bartholomew L, Mattu M, Barbato G, Ludmerer SW, Graham DJ, Altamura S, Paonessa G, De Francesco R, Migliaccio G, Carfí A. Rydberg EH, et al. Among authors: carfi a. J Mol Biol. 2009 Jul 31;390(5):1048-59. doi: 10.1016/j.jmb.2009.06.012. Epub 2009 Jun 6. J Mol Biol. 2009. PMID: 19505479

5

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A. Di Marco S, et al. Among authors: carfi a. J Biol Chem. 2005 Aug 19;280(33):29765-70. doi: 10.1074/jbc.M505423200. Epub 2005 Jun 13. J Biol Chem. 2005. PMID: 15955819 Free article.

6

Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase.

Harper S, Avolio S, Pacini B, Di Filippo M, Altamura S, Tomei L, Paonessa G, Di Marco S, Carfi A, Giuliano C, Padron J, Bonelli F, Migliaccio G, De Francesco R, Laufer R, Rowley M, Narjes F. Harper S, et al. Among authors: carfi a. J Med Chem. 2005 Jul 14;48(14):4547-57. doi: 10.1021/jm050056+. J Med Chem. 2005. PMID: 15999993

7

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

Vannini A, Volpari C, Gallinari P, Jones P, Mattu M, Carfí A, De Francesco R, Steinkühler C, Di Marco S. Vannini A, et al. Among authors: carfi a. EMBO Rep. 2007 Sep;8(9):879-84. doi: 10.1038/sj.embor.7401047. Epub 2007 Aug 10. EMBO Rep. 2007. PMID: 17721440 Free PMC article.

8

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain.

Bottomley MJ, Lo Surdo P, Di Giovine P, Cirillo A, Scarpelli R, Ferrigno F, Jones P, Neddermann P, De Francesco R, Steinkühler C, Gallinari P, Carfí A. Bottomley MJ, et al. Among authors: carfi a. J Biol Chem. 2008 Sep 26;283(39):26694-704. doi: 10.1074/jbc.M803514200. Epub 2008 Jul 8. J Biol Chem. 2008. PMID: 18614528 Free PMC article.

9

Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: the basis of the genotype 1b vs. 3a inhibitor potency shift.

Gallo M, Bottomley MJ, Pennestri M, Eliseo T, Paci M, Koch U, Bazzo R, Summa V, Carfì A, Cicero DO. Gallo M, et al. Among authors: carfi a. Virology. 2010 Sep 30;405(2):424-38. doi: 10.1016/j.virol.2010.05.035. Epub 2010 Jul 13. Virology. 2010. PMID: 20630554 Free article.

10

Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance.

Mattu M, Di Giovine P, Steinkuhler C, De Francesco R, Altamura S, Cecchetti O, Carfì A, Barbato G. Mattu M, et al. Among authors: carfi a. Anal Biochem. 2008 Jun 15;377(2):267-9. doi: 10.1016/j.ab.2008.03.028. Epub 2008 Mar 22. Anal Biochem. 2008. PMID: 18381195

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