Panchal T - Search Results

1

Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).

Panchal T, Bailey N, Bamford M, Demont E, Elliott R, Farre-Gutierrez I, Garton N, Hayhow T, Hutley G, Naylor A. Panchal T, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6813-7. doi: 10.1016/j.bmcl.2009.07.002. Epub 2009 Jul 4. Bioorg Med Chem Lett. 2009. PMID: 19846298

2

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).

Bailey N, Bamford MJ, Brissy D, Brookfield J, Demont E, Elliott R, Garton N, Farre-Gutierrez I, Hayhow T, Hutley G, Naylor A, Panchal TA, Seow HX, Spalding D, Takle AK. Bailey N, et al. Among authors: panchal ta. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6. doi: 10.1016/j.bmcl.2009.04.127. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19467868

3

(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors.

Bamford MJ, Bailey N, Davies S, Dean DK, Francis L, Panchal TA, Parr CA, Sehmi S, Steadman JG, Takle AK, Townsend JT, Wilson DM. Bamford MJ, et al. Among authors: panchal ta. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3407-11. doi: 10.1016/j.bmcl.2005.05.020. Bioorg Med Chem Lett. 2005. PMID: 15955699

4

The discovery of the benzazepine class of histamine H3 receptor antagonists.

Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Briggs MA, Calver AR, Crook B, Davis RP, Davis S, Dean DK, Harris L, Heightman TD, Panchal T, Parr CA, Quashie N, Steadman JG, Schogger J, Sehmi SS, Stean TO, Takle AK, Trail BK, White T, Witherington J, Worby A, Medhurst AD. Wilson DM, et al. Among authors: panchal t. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6897-901. doi: 10.1016/j.bmcl.2013.09.089. Epub 2013 Oct 5. Bioorg Med Chem Lett. 2013. PMID: 24161834

5

(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.

Bamford MJ, Alberti MJ, Bailey N, Davies S, Dean DK, Gaiba A, Garland S, Harling JD, Jung DK, Panchal TA, Parr CA, Steadman JG, Takle AK, Townsend JT, Wilson DM, Witherington J. Bamford MJ, et al. Among authors: panchal ta. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3402-6. doi: 10.1016/j.bmcl.2005.05.021. Bioorg Med Chem Lett. 2005. PMID: 15950465

6

Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose.

Demont EH, Arpino S, Bit RA, Campbell CA, Deeks N, Desai S, Dowell SJ, Gaskin P, Gray JR, Harrison LA, Haynes A, Heightman TD, Holmes DS, Humphreys PG, Kumar U, Morse MA, Osborne GJ, Panchal T, Philpott KL, Taylor S, Watson R, Willis R, Witherington J. Demont EH, et al. Among authors: panchal t. J Med Chem. 2011 Oct 13;54(19):6724-33. doi: 10.1021/jm200609t. Epub 2011 Sep 9. J Med Chem. 2011. PMID: 21838322

7

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.

Demont EH, Andrews BI, Bit RA, Campbell CA, Cooke JW, Deeks N, Desai S, Dowell SJ, Gaskin P, Gray JR, Haynes A, Holmes DS, Kumar U, Morse MA, Osborne GJ, Panchal T, Patel B, Perboni A, Taylor S, Watson R, Witherington J, Willis R. Demont EH, et al. Among authors: panchal t. ACS Med Chem Lett. 2011 Mar 24;2(6):444-9. doi: 10.1021/ml2000214. eCollection 2011 Jun 9. ACS Med Chem Lett. 2011. PMID: 24900328 Free PMC article.

8

Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.

Doe C, Bentley R, Behm DJ, Lafferty R, Stavenger R, Jung D, Bamford M, Panchal T, Grygielko E, Wright LL, Smith GK, Chen Z, Webb C, Khandekar S, Yi T, Kirkpatrick R, Dul E, Jolivette L, Marino JP Jr, Willette R, Lee D, Hu E. Doe C, et al. Among authors: panchal t. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. doi: 10.1124/jpet.106.110635. Epub 2006 Oct 3. J Pharmacol Exp Ther. 2007. PMID: 17018693

9

Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.

Armani E, Capaldi C, Bagnacani V, Saccani F, Aquino G, Puccini P, Facchinetti F, Martucci C, Moretto N, Villetti G, Patacchini R, Civelli M, Hurley C, Jennings A, Alcaraz L, Bloomfield D, Briggs M, Daly S, Panchal T, Russell V, Wicks S, Finch H, Fitzgerald M, Fox C, Delcanale M. Armani E, et al. Among authors: panchal t. J Med Chem. 2022 May 26;65(10):7170-7192. doi: 10.1021/acs.jmedchem.2c00115. Epub 2022 May 11. J Med Chem. 2022. PMID: 35546685

10

Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability.

Judd DB, Dowle MD, Middlemiss D, Scopes DI, Ross BC, Jack TI, Pass M, Tranquillini E, Hobson JE, Panchal TA, et al. Judd DB, et al. Among authors: panchal ta. J Med Chem. 1994 Sep 16;37(19):3108-20. doi: 10.1021/jm00045a016. J Med Chem. 1994. PMID: 7932534

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