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Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R. Andrè E, et al. Among authors: patacchini r. J Clin Invest. 2008 Jul;118(7):2574-82. doi: 10.1172/JCI34886. J Clin Invest. 2008. PMID: 18568077 Free PMC article.
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. Trevisani M, et al. Among authors: patacchini r. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13519-24. doi: 10.1073/pnas.0705923104. Epub 2007 Aug 7. Proc Natl Acad Sci U S A. 2007. PMID: 17684094 Free PMC article.
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. Nassini R, et al. Among authors: patacchini r. FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438. Epub 2010 Aug 18. FASEB J. 2010. PMID: 20720158
Transient receptor potential channels and occupational exposure.
Geppetti P, Patacchini R, Nassini R. Geppetti P, et al. Among authors: patacchini r. Curr Opin Allergy Clin Immunol. 2014 Apr;14(2):77-83. doi: 10.1097/ACI.0000000000000040. Curr Opin Allergy Clin Immunol. 2014. PMID: 24451914 Review.
TRP channels.
Benemei S, Patacchini R, Trevisani M, Geppetti P. Benemei S, et al. Among authors: patacchini r. Curr Opin Pharmacol. 2015 Jun;22:18-23. doi: 10.1016/j.coph.2015.02.006. Epub 2015 Mar 2. Curr Opin Pharmacol. 2015. PMID: 25725213 Review.
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives.
Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. Nassini R, et al. Among authors: patacchini r. Br J Pharmacol. 2015 Jul;172(13):3397-411. doi: 10.1111/bph.13129. Epub 2015 Apr 24. Br J Pharmacol. 2015. PMID: 25765567 Free PMC article.
Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.
Clay E, Patacchini R, Trevisani M, Preti D, Branà MP, Spina D, Page C. Clay E, et al. Among authors: patacchini r. J Pharmacol Exp Ther. 2016 Apr;357(1):73-83. doi: 10.1124/jpet.115.230227. Epub 2016 Feb 2. J Pharmacol Exp Ther. 2016. PMID: 26837703 Free PMC article.
203 results