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The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells.
Golay J, Cuppini L, Leoni F, Micò C, Barbui V, Domenghini M, Lombardi L, Neri A, Barbui AM, Salvi A, Pozzi P, Porro G, Pagani P, Fossati G, Mascagni P, Introna M, Rambaldi A. Golay J, et al. Among authors: mascagni p. Leukemia. 2007 Sep;21(9):1892-900. doi: 10.1038/sj.leu.2404860. Epub 2007 Jul 19. Leukemia. 2007. PMID: 17637810
Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients.
Amaru Calzada A, Pedrini O, Finazzi G, Leoni F, Mascagni P, Introna M, Rambaldi A, Golay J; Associazione Italiana per la Ricerca sul Cancro-Gruppo Italiano Malattie Mieloproliferative Investigators. Amaru Calzada A, et al. Among authors: mascagni p. Exp Hematol. 2013 Mar;41(3):253-60.e2. doi: 10.1016/j.exphem.2012.10.013. Epub 2012 Oct 27. Exp Hematol. 2013. PMID: 23111067 Free article.
Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation.
Angiolilli C, Kabala PA, Grabiec AM, Rossato M, Lai WS, Fossati G, Mascagni P, Steinkühler C, Blackshear PJ, Reedquist KA, Baeten DL, Radstake TRDJ. Angiolilli C, et al. Among authors: mascagni p. Arthritis Res Ther. 2018 Jul 20;20(1):148. doi: 10.1186/s13075-018-1638-4. Arthritis Res Ther. 2018. PMID: 30029685 Free PMC article.
The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.
Matalon S, Palmer BE, Nold MF, Furlan A, Kassu A, Fossati G, Mascagni P, Dinarello CA. Matalon S, et al. Among authors: mascagni p. J Acquir Immune Defic Syndr. 2010 May 1;54(1):1-9. doi: 10.1097/QAI.0b013e3181d3dca3. J Acquir Immune Defic Syndr. 2010. PMID: 20300007 Free PMC article.
228 results