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Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.
Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT. Wang L, et al. Among authors: zhang k. J Am Coll Cardiol. 2009 Sep 1;54(10):944-54. doi: 10.1016/j.jacc.2009.05.035. J Am Coll Cardiol. 2009. PMID: 19712806 Free PMC article.
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.
Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT. Rao F, et al. Among authors: zhang l, zhang k. Circulation. 2007 Aug 28;116(9):993-1006. doi: 10.1161/CIRCULATIONAHA.106.682302. Epub 2007 Aug 13. Circulation. 2007. PMID: 17698732
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.
Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, O'Connor DT. Zhang L, et al. Among authors: zhang k. J Clin Invest. 2007 Sep;117(9):2658-71. doi: 10.1172/JCI31093. J Clin Invest. 2007. PMID: 17717598 Free PMC article.
Adrenergic polymorphism and the human stress response.
Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT. Rao F, et al. Among authors: zhang l, zhang k. Ann N Y Acad Sci. 2008 Dec;1148:282-96. doi: 10.1196/annals.1410.085. Ann N Y Acad Sci. 2008. PMID: 19120120 Free PMC article.
Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.
Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton BA, O'Connor DT. Chen Y, et al. Among authors: zhang k. J Hypertens. 2010 Jan;28(1):76-86. doi: 10.1097/HJH.0b013e328332bc87. J Hypertens. 2010. PMID: 20009769 Free PMC article.
Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.
Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton BA, O'Connor DT. Rodríguez-Flores JL, et al. Among authors: zhang k. Mamm Genome. 2010 Apr;21(3-4):195-204. doi: 10.1007/s00335-010-9253-y. Epub 2010 Mar 5. Mamm Genome. 2010. PMID: 20204374 Free PMC article.
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