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The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA. Yu M, et al. Among authors: falkard b. Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001. Cell Host Microbe. 2008. PMID: 19064257 Free PMC article.
A key role for lipoic acid synthesis during Plasmodium liver stage development.
Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. Falkard B, et al. Cell Microbiol. 2013 Sep;15(9):1585-604. doi: 10.1111/cmi.12137. Epub 2013 Apr 5. Cell Microbiol. 2013. PMID: 23490300 Free PMC article.
Inhibition of HIV-1 replication by eIF3f.
Valente ST, Gilmartin GM, Mott C, Falkard B, Goff SP. Valente ST, et al. Among authors: falkard b. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4071-8. doi: 10.1073/pnas.0900557106. Epub 2009 Feb 23. Proc Natl Acad Sci U S A. 2009. PMID: 19237569 Free PMC article.
Flt3 agonist enhances immunogenicity of arenavirus vector-based simian immunodeficiency virus vaccine in macaques.
Boopathy AV, Nekkalapudi A, Sung J, Schulha S, Jin D, Sharma B, Ng S, Lu S, Wimmer R, Suthram S, Ahmadi-Erber S, Lauterbach H, Orlinger KK, Hung M, Carr B, Callebaut C, Geleziunas R, Kuhne M, Schmidt S, Falkard B. Boopathy AV, et al. Among authors: falkard b. J Virol. 2024 Jul 23;98(7):e0029424. doi: 10.1128/jvi.00294-24. Epub 2024 Jun 3. J Virol. 2024. PMID: 38829139 Free PMC article.
Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys.
Boopathy AV, Sharma B, Nekkalapudi A, Wimmer R, Gamez-Guerrero M, Suthram S, Truong H, Lee J, Li J, Martin R, Blair W, Geleziunas R, Orlinger K, Ahmadi-Erber S, Lauterbach H, Makadzange T, Falkard B, Schmidt S. Boopathy AV, et al. Among authors: falkard b. NPJ Vaccines. 2023 Nov 10;8(1):175. doi: 10.1038/s41541-023-00768-x. NPJ Vaccines. 2023. PMID: 37945621 Free PMC article.
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