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DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands.
End C, Bikker F, Renner M, Bergmann G, Lyer S, Blaich S, Hudler M, Helmke B, Gassler N, Autschbach F, Ligtenberg AJ, Benner A, Holmskov U, Schirmacher P, Nieuw Amerongen AV, Rosenstiel P, Sina C, Franke A, Hafner M, Kioschis P, Schreiber S, Poustka A, Mollenhauer J. End C, et al. Eur J Immunol. 2009 Mar;39(3):833-42. doi: 10.1002/eji.200838689. Eur J Immunol. 2009. PMID: 19189310 Free article.
DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.
Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, Helmke B, Gassler N, Autschbach F, Bikker F, Strobel-Freidekind O, Gronert-Sum S, Benner A, Blaich S, Wittig R, Hudler M, Ligtenberg AJ, Madsen J, Holmskov U, Annese V, Latiano A, Schirmacher P, Amerongen AV, D'Amato M, Kioschis P, Hafner M, Poustka A, Mollenhauer J. Renner M, et al. Among authors: end c. Gastroenterology. 2007 Nov;133(5):1499-509. doi: 10.1053/j.gastro.2007.08.007. Epub 2007 Aug 3. Gastroenterology. 2007. PMID: 17983803
The scavenging capacity of DMBT1 is impaired by germline deletions.
Bikker FJ, End C, Ligtenberg AJM, Blaich S, Lyer S, Renner M, Wittig R, Nazmi K, van Nieuw Amerongen A, Poustka A, Veerman ECI, Mollenhauer J. Bikker FJ, et al. Among authors: end c. Immunogenetics. 2017 Jun;69(6):401-407. doi: 10.1007/s00251-017-0982-x. Epub 2017 Mar 31. Immunogenetics. 2017. PMID: 28364129 Free PMC article.
Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains.
Bikker FJ, Ligtenberg AJ, End C, Renner M, Blaich S, Lyer S, Wittig R, van't Hof W, Veerman EC, Nazmi K, de Blieck-Hogervorst JM, Kioschis P, Nieuw Amerongen AV, Poustka A, Mollenhauer J. Bikker FJ, et al. Among authors: end c. J Biol Chem. 2004 Nov 12;279(46):47699-703. doi: 10.1074/jbc.M406095200. Epub 2004 Sep 7. J Biol Chem. 2004. PMID: 15355985 Free article.
23 results