Wang Y - Search Results

1

In vivo structural activity and optimization studies of folate-tubulysin conjugates.

Reddy JA, Dorton R, Dawson A, Vetzel M, Parker N, Nicoson JS, Westrick E, Klein PJ, Wang Y, Vlahov IR, Leamon CP. Reddy JA, et al. Among authors: wang y. Mol Pharm. 2009 Sep-Oct;6(5):1518-25. doi: 10.1021/mp900086w. Mol Pharm. 2009. PMID: 19630399

2

Preclinical antitumor activity of a novel folate-targeted dual drug conjugate.

Leamon CP, Reddy JA, Vlahov IR, Westrick E, Dawson A, Dorton R, Vetzel M, Santhapuram HK, Wang Y. Leamon CP, et al. Among authors: wang y. Mol Pharm. 2007 Sep-Oct;4(5):659-67. doi: 10.1021/mp070049c. Epub 2007 Sep 18. Mol Pharm. 2007. PMID: 17874843

3

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides.

Vlahov IR, Wang Y, Kleindl PJ, Leamon CP. Vlahov IR, et al. Among authors: wang y. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4558-61. doi: 10.1016/j.bmcl.2008.07.041. Epub 2008 Jul 15. Bioorg Med Chem Lett. 2008. PMID: 18657420

4

Folate targeting enables durable and specific antitumor responses from a therapeutically null tubulysin B analogue.

Leamon CP, Reddy JA, Vetzel M, Dorton R, Westrick E, Parker N, Wang Y, Vlahov I. Leamon CP, et al. Among authors: wang y. Cancer Res. 2008 Dec 1;68(23):9839-44. doi: 10.1158/0008-5472.CAN-08-2341. Cancer Res. 2008. PMID: 19047164

5

Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates.

Vlahov IR, Santhapuram HK, You F, Wang Y, Kleindl PJ, Hahn SJ, Vaughn JF, Reno DS, Leamon CP. Vlahov IR, et al. Among authors: wang y. J Org Chem. 2010 Jun 4;75(11):3685-91. doi: 10.1021/jo100448q. J Org Chem. 2010. PMID: 20423159

6

Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy.

Leamon CP, Reddy JA, Vlahov IR, Dorton R, Bloomfield A, Vetzel M, Klein PJ, Westrick E, Xu LC, Wang Y. Leamon CP, et al. Among authors: wang y. Cancer Chemother Pharmacol. 2017 Jun;79(6):1151-1160. doi: 10.1007/s00280-017-3311-z. Epub 2017 Apr 27. Cancer Chemother Pharmacol. 2017. PMID: 28451831

7

An assembly concept for the consecutive introduction of unsymmetrical disulfide bonds: synthesis of a releasable multidrug conjugate of folic acid.

Vlahov IR, Santhapuram HK, Wang Y, Kleindl PJ, You F, Howard SJ, Westrick E, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: wang y. J Org Chem. 2007 Aug 3;72(16):5968-72. doi: 10.1021/jo070411z. Epub 2007 Jun 29. J Org Chem. 2007. PMID: 17602528

8

Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid.

Vlahov IR, Vite GD, Kleindl PJ, Wang Y, Santhapuram HK, You F, Howard SJ, Kim SH, Lee FF, Leamon CP. Vlahov IR, et al. Among authors: wang y. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4578-81. doi: 10.1016/j.bmcl.2010.06.016. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20594844

9

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation.

Vlahov IR, You F, Santhapuram HK, Wang Y, Vaughn JF, Hahn SJ, Kleindl PJ, Fan M, Leamon CP. Vlahov IR, et al. Among authors: wang y. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1202-5. doi: 10.1016/j.bmcl.2010.12.085. Epub 2010 Dec 22. Bioorg Med Chem Lett. 2011. PMID: 21236665

10

Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs.

Vlahov IR, Wang Y, Vetzel M, Hahn S, Kleindl PJ, Reddy JA, Leamon CP. Vlahov IR, et al. Among authors: wang y. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. doi: 10.1016/j.bmcl.2011.09.041. Epub 2011 Sep 17. Bioorg Med Chem Lett. 2011. PMID: 21974954

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