Bruner SD - Search Results

1

Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes.

Cooke HA, Christianson CV, Bruner SD. Cooke HA, et al. Among authors: bruner sd. Curr Opin Chem Biol. 2009 Oct;13(4):460-8. doi: 10.1016/j.cbpa.2009.06.013. Epub 2009 Jul 19. Curr Opin Chem Biol. 2009. PMID: 19620019 Review.

2

The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway.

Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. Christianson CV, et al. Among authors: bruner sd. Biochemistry. 2007 Jun 19;46(24):7205-14. doi: 10.1021/bi7003685. Epub 2007 May 22. Biochemistry. 2007. PMID: 17516659

3

The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis.

Christianson CV, Montavon TJ, Festin GM, Cooke HA, Shen B, Bruner SD. Christianson CV, et al. Among authors: bruner sd. J Am Chem Soc. 2007 Dec 26;129(51):15744-5. doi: 10.1021/ja0762689. Epub 2007 Dec 5. J Am Chem Soc. 2007. PMID: 18052279

4

Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites.

Cooke HA, Bruner SD. Cooke HA, et al. Among authors: bruner sd. Biopolymers. 2010 Sep;93(9):802-10. doi: 10.1002/bip.21500. Biopolymers. 2010. PMID: 20577998 Free PMC article.

5

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD. Cooke HA, et al. Among authors: bruner sd. J Am Chem Soc. 2007 Jun 27;129(25):7728-9. doi: 10.1021/ja071886a. Epub 2007 Jun 1. J Am Chem Soc. 2007. PMID: 17539640 No abstract available.

6

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM.

Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD. Montavon TJ, et al. Among authors: bruner sd. Bioorg Med Chem Lett. 2008 May 15;18(10):3099-102. doi: 10.1016/j.bmcl.2007.11.046. Epub 2007 Nov 19. Bioorg Med Chem Lett. 2008. PMID: 18078753 Free PMC article.

7

Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Cooke HA, et al. Among authors: bruner sd. Biochemistry. 2009 Oct 13;48(40):9590-8. doi: 10.1021/bi901257q. Biochemistry. 2009. PMID: 19702337 Free PMC article.

8

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B. Luo Y, et al. Among authors: bruner sd. J Biol Chem. 2008 May 23;283(21):14694-702. doi: 10.1074/jbc.M802206200. Epub 2008 Apr 3. J Biol Chem. 2008. PMID: 18387946 Free PMC article.

9

Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases.

Liu Y, Zheng T, Bruner SD. Liu Y, et al. Among authors: bruner sd. Chem Biol. 2011 Nov 23;18(11):1482-8. doi: 10.1016/j.chembiol.2011.09.018. Chem Biol. 2011. PMID: 22118682 Free PMC article.

10

Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways.

Condurso HL, Bruner SD. Condurso HL, et al. Among authors: bruner sd. Curr Opin Chem Biol. 2012 Apr;16(1-2):162-9. doi: 10.1016/j.cbpa.2012.02.002. Epub 2012 Feb 25. Curr Opin Chem Biol. 2012. PMID: 22369855 Review.

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