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The impact of individual human immunodeficiency virus type 1 protease mutations on drug susceptibility is highly influenced by complex interactions with the background protease sequence.
Van Marck H, Dierynck I, Kraus G, Hallenberger S, Pattery T, Muyldermans G, Geeraert L, Borozdina L, Bonesteel R, Aston C, Shaw E, Chen Q, Martinez C, Koka V, Lee J, Chi E, de Béthune MP, Hertogs K. Van Marck H, et al. Among authors: bonesteel r. J Virol. 2009 Sep;83(18):9512-20. doi: 10.1128/JVI.00291-09. Epub 2009 Jul 8. J Virol. 2009. PMID: 19587054 Free PMC article.
Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
Edwards W, Fung-Leung WP, Huang C, Chi E, Wu N, Liu Y, Maher MP, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson RV, Wickenden AD. Edwards W, et al. Among authors: bonesteel r. J Biol Chem. 2014 Aug 15;289(33):22704-22714. doi: 10.1074/jbc.M114.568642. Epub 2014 Jun 17. J Biol Chem. 2014. PMID: 24939846 Free PMC article.
Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.
Flinspach M, Xu Q, Piekarz AD, Fellows R, Hagan R, Gibbs A, Liu Y, Neff RA, Freedman J, Eckert WA, Zhou M, Bonesteel R, Pennington MW, Eddinger KA, Yaksh TL, Hunter M, Swanson RV, Wickenden AD. Flinspach M, et al. Among authors: bonesteel r. Sci Rep. 2017 Jan 3;7:39662. doi: 10.1038/srep39662. Sci Rep. 2017. PMID: 28045073 Free PMC article.