Tsalkova T - Search Results

1

Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities.

Tsalkova T, Blumenthal DK, Mei FC, White MA, Cheng X. Tsalkova T, et al. J Biol Chem. 2009 Aug 28;284(35):23644-51. doi: 10.1074/jbc.M109.024950. Epub 2009 Jun 24. J Biol Chem. 2009. PMID: 19553663 Free PMC article.

2

Epac and PKA: a tale of two intracellular cAMP receptors.

Cheng X, Ji Z, Tsalkova T, Mei F. Cheng X, et al. Among authors: tsalkova t. Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):651-62. doi: 10.1111/j.1745-7270.2008.00438.x. Acta Biochim Biophys Sin (Shanghai). 2008. PMID: 18604457 Free PMC article. Review.

3

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).

Li S, Tsalkova T, White MA, Mei FC, Liu T, Wang D, Woods VL Jr, Cheng X. Li S, et al. Among authors: tsalkova t. J Biol Chem. 2011 May 20;286(20):17889-97. doi: 10.1074/jbc.M111.224535. Epub 2011 Mar 17. J Biol Chem. 2011. PMID: 21454623 Free PMC article.

4

A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists.

Tsalkova T, Mei FC, Cheng X. Tsalkova T, et al. PLoS One. 2012;7(1):e30441. doi: 10.1371/journal.pone.0030441. Epub 2012 Jan 19. PLoS One. 2012. PMID: 22276201 Free PMC article.

5

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.

Chen H, Tsalkova T, Mei FC, Hu Y, Cheng X, Zhou J. Chen H, et al. Among authors: tsalkova t. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. doi: 10.1016/j.bmcl.2012.04.082. Epub 2012 Apr 26. Bioorg Med Chem Lett. 2012. PMID: 22607683 Free PMC article.

6

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X. Almahariq M, et al. Among authors: tsalkova t. Mol Pharmacol. 2013 Jan;83(1):122-8. doi: 10.1124/mol.112.080689. Epub 2012 Oct 11. Mol Pharmacol. 2013. PMID: 23066090 Free PMC article.

7

Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X. Tsalkova T, et al. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi: 10.1073/pnas.1210209109. Epub 2012 Oct 22. Proc Natl Acad Sci U S A. 2012. PMID: 23091014 Free PMC article.

8

Structural analyses of a constitutively active mutant of exchange protein directly activated by cAMP.

White MA, Li S, Tsalkova T, Mei FC, Liu T, Woods VL Jr, Cheng X. White MA, et al. Among authors: tsalkova t. PLoS One. 2012;7(11):e49932. doi: 10.1371/journal.pone.0049932. Epub 2012 Nov 26. PLoS One. 2012. PMID: 23189173 Free PMC article.

9

Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J. Chen H, et al. Among authors: tsalkova t. J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23286832 Free PMC article.

10

Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology.

White MA, Tsalkova T, Mei FC, Cheng X. White MA, et al. Among authors: tsalkova t. Cells. 2019 Dec 21;9(1):35. doi: 10.3390/cells9010035. Cells. 2019. PMID: 31877746 Free PMC article.

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