Weerakkody GJ - Search Results

1

Population pharmacokinetic analyses to evaluate the influence of intrinsic and extrinsic factors on exposure of prasugrel active metabolite in TRITON-TIMI 38.

Wrishko RE, Ernest CS 2nd, Small DS, Li YG, Weerakkody GJ, Riesmeyer JR, Macias WL, Rohatagi S, Salazar DE, Antman EM, Wiviott SD, Braunwald E, Ni L. Wrishko RE, et al. Among authors: weerakkody gj. J Clin Pharmacol. 2009 Aug;49(8):984-98. doi: 10.1177/0091270009337942. Epub 2009 Jun 22. J Clin Pharmacol. 2009. PMID: 19546250

2

Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial.

Wiviott SD, Antman EM, Winters KJ, Weerakkody G, Murphy SA, Behounek BD, Carney RJ, Lazzam C, McKay RG, McCabe CH, Braunwald E; JUMBO-TIMI 26 Investigators. Wiviott SD, et al. Circulation. 2005 Jun 28;111(25):3366-73. doi: 10.1161/CIRCULATIONAHA.104.502815. Epub 2005 Jun 20. Circulation. 2005. PMID: 15967851 Clinical Trial.

3

The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects.

Jakubowski JA, Payne CD, Brandt JT, Weerakkody GJ, Farid NA, Small DS, Naganuma H, Li GY, Winters KJ. Jakubowski JA, et al. Among authors: weerakkody gj. J Cardiovasc Pharmacol. 2006 Mar;47(3):377-84. doi: 10.1097/01.fjc.0000210069.47205.c0. J Cardiovasc Pharmacol. 2006. PMID: 16633079 Clinical Trial.

4

Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38).

Wiviott SD, Antman EM, Gibson CM, Montalescot G, Riesmeyer J, Weerakkody G, Winters KJ, Warmke JW, McCabe CH, Braunwald E; TRITON-TIMI 38 Investigators. Wiviott SD, et al. Am Heart J. 2006 Oct;152(4):627-35. doi: 10.1016/j.ahj.2006.04.012. Am Heart J. 2006. PMID: 16996826 Clinical Trial.

5

A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

Brandt JT, Payne CD, Wiviott SD, Weerakkody G, Farid NA, Small DS, Jakubowski JA, Naganuma H, Winters KJ. Brandt JT, et al. Am Heart J. 2007 Jan;153(1):66.e9-16. doi: 10.1016/j.ahj.2006.10.010. Am Heart J. 2007. PMID: 17174640 Clinical Trial.

6

Stereoselective metabolism of prasugrel in humans using a novel chiral liquid chromatography-tandem mass spectrometry method.

Wickremsinhe ER, Tian Y, Ruterbories KJ, Verburg EM, Weerakkody GJ, Kurihara A, Farid NA. Wickremsinhe ER, et al. Among authors: weerakkody gj. Drug Metab Dispos. 2007 Jun;35(6):917-21. doi: 10.1124/dmd.106.014530. Epub 2007 Mar 12. Drug Metab Dispos. 2007. PMID: 17353347 Clinical Trial.

7

Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.

Jakubowski JA, Payne CD, Weerakkody GJ, Brandt JT, Farid NA, Li YG, Naganuma H, Lachno DR, Winters KJ. Jakubowski JA, et al. Among authors: weerakkody gj. J Cardiovasc Pharmacol. 2007 Mar;49(3):167-73. doi: 10.1097/FJC.0b013e318031301b. J Cardiovasc Pharmacol. 2007. PMID: 17414229 Clinical Trial.

8

Comparison of speed of onset of platelet inhibition after loading doses of clopidogrel versus prasugrel in healthy volunteers and correlation with responder status.

Weerakkody GJ, Jakubowski JA, Brandt JT, Farid NA, Payne CD, Zhu J, Warner MR, Naganuma H, Winters KJ. Weerakkody GJ, et al. Am J Cardiol. 2007 Jul 15;100(2):331-6. doi: 10.1016/j.amjcard.2007.02.103. Epub 2007 May 25. Am J Cardiol. 2007. PMID: 17631093

9

Greater inhibition of platelet aggregation and reduced response variability with prasugrel versus clopidogrel: an integrated analysis.

Weerakkody GJ, Jakubowski JA, Brandt JT, Payne CD, Naganuma H, Winters KJ. Weerakkody GJ, et al. J Cardiovasc Pharmacol Ther. 2007 Sep;12(3):205-12. doi: 10.1177/1074248407304731. J Cardiovasc Pharmacol Ther. 2007. PMID: 17875947

10

Prasugrel versus clopidogrel in patients with acute coronary syndromes.

Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, Neumann FJ, Ardissino D, De Servi S, Murphy SA, Riesmeyer J, Weerakkody G, Gibson CM, Antman EM; TRITON-TIMI 38 Investigators. Wiviott SD, et al. N Engl J Med. 2007 Nov 15;357(20):2001-15. doi: 10.1056/NEJMoa0706482. Epub 2007 Nov 4. N Engl J Med. 2007. PMID: 17982182 Free article. Clinical Trial.

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