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Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Xue B, et al. Among authors: pulinilkunnil t. Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15. Mol Cell Biol. 2009. PMID: 19528236 Free PMC article.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Kraus D, et al. Among authors: pulinilkunnil tc. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. Nature. 2014. PMID: 24717514 Free PMC article.
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR. Fullerton MD, et al. Among authors: pulinilkunnil t. Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3. Nat Med. 2013. PMID: 24185692 Free PMC article.
AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.
O'Neill HM, Lally JS, Galic S, Thomas M, Azizi PD, Fullerton MD, Smith BK, Pulinilkunnil T, Chen Z, Samaan MC, Jorgensen SB, Dyck JR, Holloway GP, Hawke TJ, van Denderen BJ, Kemp BE, Steinberg GR. O'Neill HM, et al. Among authors: pulinilkunnil t. Diabetologia. 2014 Aug;57(8):1693-702. doi: 10.1007/s00125-014-3273-1. Epub 2014 Jun 10. Diabetologia. 2014. PMID: 24913514
Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity.
Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, DeLany JP, Schreiber R, Stolz DB, Gardner NP, Kienesberger PC, Pulinilkunnil T, Zechner R, Goodpaster BH, Coen P, Kershaw EE. Sitnick MT, et al. Among authors: pulinilkunnil t. Diabetes. 2013 Oct;62(10):3350-61. doi: 10.2337/db13-0500. Epub 2013 Jul 8. Diabetes. 2013. PMID: 23835334 Free PMC article.
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.
Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE. Kienesberger PC, et al. Among authors: pulinilkunnil t. J Biol Chem. 2009 Oct 30;284(44):30218-29. doi: 10.1074/jbc.M109.047787. Epub 2009 Aug 31. J Biol Chem. 2009. PMID: 19723629 Free PMC article.
80 results