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Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Xue B, et al. Among authors: furukawa n. Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15. Mol Cell Biol. 2009. PMID: 19528236 Free PMC article.
Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues.
Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E. Kojima K, et al. Among authors: furukawa n. Biochem Biophys Res Commun. 2008 Nov 14;376(2):434-8. doi: 10.1016/j.bbrc.2008.09.007. Epub 2008 Sep 19. Biochem Biophys Res Commun. 2008. PMID: 18789895
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E. Murata Y, et al. Among authors: furukawa n. Biochem Biophys Res Commun. 2007 Dec 14;364(2):301-7. doi: 10.1016/j.bbrc.2007.10.007. Epub 2007 Oct 12. Biochem Biophys Res Commun. 2007. PMID: 17950694
Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E. Adachi H, et al. Among authors: furukawa n. Biochem Biophys Res Commun. 2009 Feb 20;379(4):806-11. doi: 10.1016/j.bbrc.2008.12.018. Epub 2008 Dec 16. Biochem Biophys Res Commun. 2009. PMID: 19094966
Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice.
Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E. Tsutsumi A, et al. Among authors: furukawa n. Biochem Biophys Res Commun. 2011 Jan 7;404(1):339-44. doi: 10.1016/j.bbrc.2010.11.120. Epub 2010 Dec 4. Biochem Biophys Res Commun. 2011. PMID: 21134353
362 results