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Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG. Ferwerda B, et al. Among authors: schumann rr. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10272-7. doi: 10.1073/pnas.0811273106. Epub 2009 Jun 9. Proc Natl Acad Sci U S A. 2009. PMID: 19509334 Free PMC article.
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.
Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, Eckert J, Oh NR, Otchwemah RN, Dietz E, Ehrhardt S, Schröder NW, Bienzle U, Schumann RR. Mockenhaupt FP, et al. Among authors: schumann rr. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):177-82. doi: 10.1073/pnas.0506803102. Epub 2005 Dec 21. Proc Natl Acad Sci U S A. 2006. PMID: 16371473 Free PMC article.
Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome.
Zacharowski K, Zacharowski PA, Koch A, Baban A, Tran N, Berkels R, Papewalis C, Schulze-Osthoff K, Knuefermann P, Zähringer U, Schumann RR, Rettori V, McCann SM, Bornstein SR. Zacharowski K, et al. Among authors: schumann rr. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6392-7. doi: 10.1073/pnas.0601527103. Epub 2006 Apr 10. Proc Natl Acad Sci U S A. 2006. PMID: 16606831 Free PMC article.
164 results