Labro AJ - Search Results

1

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.

Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ. Kopljar I, et al. Among authors: labro aj. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9896-901. doi: 10.1073/pnas.0812471106. Epub 2009 May 29. Proc Natl Acad Sci U S A. 2009. PMID: 19482941 Free PMC article.

2

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.

Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ. Labro AJ, et al. J Biol Chem. 2003 Dec 12;278(50):50724-31. doi: 10.1074/jbc.M306097200. Epub 2003 Sep 17. J Biol Chem. 2003. PMID: 13679372 Free article.

3

Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.

Labro AJ, Raes AL, Snyders DJ. Labro AJ, et al. J Gen Physiol. 2005 Jan;125(1):71-80. doi: 10.1085/jgp.200409194. J Gen Physiol. 2005. PMID: 15623896 Free PMC article.

4

Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.

Saenen JB, Labro AJ, Raes A, Snyders DJ. Saenen JB, et al. Among authors: labro aj. Biophys J. 2006 Dec 15;91(12):4381-91. doi: 10.1529/biophysj.106.087247. Epub 2006 Sep 22. Biophys J. 2006. PMID: 16997865 Free PMC article.

5

Role of the S6 C-terminus in KCNQ1 channel gating.

Boulet IR, Labro AJ, Raes AL, Snyders DJ. Boulet IR, et al. Among authors: labro aj. J Physiol. 2007 Dec 1;585(Pt 2):325-37. doi: 10.1113/jphysiol.2007.145813. Epub 2007 Oct 11. J Physiol. 2007. PMID: 17932138 Free PMC article.

6

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ. Labro AJ, et al. Am J Physiol Cell Physiol. 2008 Jun;294(6):C1476-84. doi: 10.1152/ajpcell.00479.2007. Epub 2008 Apr 2. Am J Physiol Cell Physiol. 2008. PMID: 18385285 Free article.

7

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.

Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ. Labro AJ, et al. J Gen Physiol. 2008 Dec;132(6):667-80. doi: 10.1085/jgp.200810048. J Gen Physiol. 2008. PMID: 19029374 Free PMC article.

8

Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.

Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ. Bocksteins E, et al. Among authors: labro aj. J Biol Chem. 2009 Nov 13;284(46):31625-34. doi: 10.1074/jbc.M109.039479. Epub 2009 Aug 28. J Biol Chem. 2009. PMID: 19717558 Free PMC article.

9

The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.

Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ. Labro AJ, et al. J Mol Cell Cardiol. 2010 Jun;48(6):1096-104. doi: 10.1016/j.yjmcc.2009.10.027. Epub 2009 Nov 11. J Mol Cell Cardiol. 2010. PMID: 19913547 Review.

10

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G. Choveau FS, et al. Among authors: labro aj. J Biol Chem. 2011 Jan 7;286(1):707-16. doi: 10.1074/jbc.M110.146324. Epub 2010 Oct 12. J Biol Chem. 2011. PMID: 20940310 Free PMC article.

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