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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.
Mol Cell Biol. 2009 Aug;29(15):4080-90. doi: 10.1128/MCB.00483-09. Epub 2009 May 26.
Mol Cell Biol. 2009.
PMID: 19470762
Free PMC article.
Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma.
Sourbier C, Valera-Romero V, Giubellino A, Yang Y, Sudarshan S, Neckers L, Linehan WM.
Sourbier C, et al.
Cell Cycle. 2010 Oct 15;9(20):4183-9. doi: 10.4161/cc.9.20.13458. Epub 2010 Oct 27.
Cell Cycle. 2010.
PMID: 20953139
Free PMC article.
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