Leon CG - Search Results

1

Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.

Gershkovich P, Wasan EK, Lin M, Sivak O, Leon CG, Clement JG, Wasan KM. Gershkovich P, et al. Among authors: leon cg. J Antimicrob Chemother. 2009 Jul;64(1):101-8. doi: 10.1093/jac/dkp140. Epub 2009 Apr 27. J Antimicrob Chemother. 2009. PMID: 19398459

2

Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans.

Wasan EK, Bartlett K, Gershkovich P, Sivak O, Banno B, Wong Z, Gagnon J, Gates B, Leon CG, Wasan KM. Wasan EK, et al. Among authors: leon cg. Int J Pharm. 2009 May 8;372(1-2):76-84. doi: 10.1016/j.ijpharm.2009.01.003. Epub 2009 Jan 17. Int J Pharm. 2009. PMID: 19236839

3

Differences in human phospholipid transfer protein activity following incubation of Fungizone compared to lipid-based Amphotericin-B formulations in normolipidemic and hyperlipidemic plasma.

Henderson RJ, Leon CG, Wasan KM. Henderson RJ, et al. Among authors: leon cg. Drug Dev Ind Pharm. 2009 Sep;35(9):1139-46. doi: 10.1080/03639040902824852. Drug Dev Ind Pharm. 2009. PMID: 19381990

4

In vitro cytotoxicity of two novel oral formulations of Amphotericin B (iCo-009 and iCo-010) against Candida albicans, human monocytic and kidney cell lines.

Leon CG, Lee J, Bartlett K, Gershkovich P, Wasan EK, Zhao J, Clement JG, Wasan KM. Leon CG, et al. Lipids Health Dis. 2011 Aug 20;10:144. doi: 10.1186/1476-511X-10-144. Lipids Health Dis. 2011. PMID: 21854638 Free PMC article.

5

Effect of heat-treatment and the role of phospholipases on Fungizone-induced cytotoxicity within human kidney proximal tubular (HK-2) cells and Aspergillus fumigatus.

Leon C, Taylor R, Bartlett KH, Wasan KM. Leon C, et al. Int J Pharm. 2005 Jul 14;298(1):211-8. doi: 10.1016/j.ijpharm.2005.04.018. Int J Pharm. 2005. PMID: 15950412

6

Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases.

Leon CG, Tory R, Jia J, Sivak O, Wasan KM. Leon CG, et al. Pharm Res. 2008 Aug;25(8):1751-61. doi: 10.1007/s11095-008-9571-x. Epub 2008 May 21. Pharm Res. 2008. PMID: 18493843 Free PMC article. Review.

7

Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma.

Henderson RJ, Wasan KM, Leon CG. Henderson RJ, et al. Among authors: leon cg. Lipids Health Dis. 2009 Jul 23;8:27. doi: 10.1186/1476-511X-8-27. Lipids Health Dis. 2009. PMID: 19627602 Free PMC article.

8

Cholesterol as a potential target for castration-resistant prostate cancer.

Twiddy AL, Leon CG, Wasan KM. Twiddy AL, et al. Among authors: leon cg. Pharm Res. 2011 Mar;28(3):423-37. doi: 10.1007/s11095-010-0210-y. Epub 2010 Aug 4. Pharm Res. 2011. PMID: 20683646 Review.

9

Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.

Leon C, Hill JS, Wasan KM. Leon C, et al. Pharm Res. 2005 Oct;22(10):1578-88. doi: 10.1007/s11095-005-6306-0. Epub 2005 Sep 22. Pharm Res. 2005. PMID: 16180116 Review.

10

Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression.

Leon C, Wasan KM, Sachs-Barrable K, Johnston TP. Leon C, et al. Pharm Res. 2006 Jul;23(7):1597-607. doi: 10.1007/s11095-006-0276-8. Epub 2006 Jun 21. Pharm Res. 2006. PMID: 16783477

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