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Design, synthesis, and studies of small molecule STAT3 inhibitors.
Bhasin D, Cisek K, Pandharkar T, Regan N, Li C, Pandit B, Lin J, Li PK. Bhasin D, et al. Among authors: li c, li pk. Bioorg Med Chem Lett. 2008 Jan 1;18(1):391-5. doi: 10.1016/j.bmcl.2007.10.031. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18006313
Curcumin is a potent DNA hypomethylation agent.
Liu Z, Xie Z, Jones W, Pavlovicz RE, Liu S, Yu J, Li PK, Lin J, Fuchs JR, Marcucci G, Li C, Chan KK. Liu Z, et al. Among authors: li c, li pk. Bioorg Med Chem Lett. 2009 Feb 1;19(3):706-9. doi: 10.1016/j.bmcl.2008.12.041. Epub 2008 Dec 14. Bioorg Med Chem Lett. 2009. PMID: 19112019
Modulation of DNA methylation by a sesquiterpene lactone parthenolide.
Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, Aimiuwu J, Pang J, Bhasin D, Neviani P, Fuchs JR, Plass C, Li PK, Li C, Huang TH, Wu LC, Rush L, Wang H, Perrotti D, Marcucci G, Chan KK. Liu Z, et al. Among authors: li c, li pk. J Pharmacol Exp Ther. 2009 May;329(2):505-14. doi: 10.1124/jpet.108.147934. Epub 2009 Feb 6. J Pharmacol Exp Ther. 2009. PMID: 19201992 Free PMC article.
Structure-activity relationship studies of curcumin analogues.
Fuchs JR, Pandit B, Bhasin D, Etter JP, Regan N, Abdelhamid D, Li C, Lin J, Li PK. Fuchs JR, et al. Among authors: li c, li pk. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2065-9. doi: 10.1016/j.bmcl.2009.01.104. Epub 2009 Feb 5. Bioorg Med Chem Lett. 2009. PMID: 19249204
New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.
Lin L, Hutzen B, Ball S, Foust E, Sobo M, Deangelis S, Pandit B, Friedman L, Li C, Li PK, Fuchs J, Lin J. Lin L, et al. Among authors: li c, li pk. Cancer Sci. 2009 Sep;100(9):1719-27. doi: 10.1111/j.1349-7006.2009.01220.x. Epub 2009 May 18. Cancer Sci. 2009. PMID: 19558577 Free PMC article.
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