Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.
van Vliet VJE, Huynh N, Palà J, Patel A, Singer A, Slater C, Chung J, van Huizen M, Teyra J, Miersch S, Luu GK, Ye W, Sharma N, Ganaie SS, Russell R, Chen C, Maynard M, Amarasinghe GK, Mark BL, Kikkert M, Sidhu SS.
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PLoS Pathog. 2022 Dec 22;18(12):e1011065. doi: 10.1371/journal.ppat.1011065. eCollection 2022 Dec.
PLoS Pathog. 2022.
PMID: 36548304
Free PMC article.