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Synthesis of Deuterated Endochin-Like Quinolones.
Pou S, Winter RW, Liebman KM, Dodean RA, Nilsen A, DeBarber A, Doggett JS, Riscoe MK. Pou S, et al. Among authors: nilsen a. J Labelled Comp Radiopharm. 2024 May 15;67(5):186-196. doi: 10.1002/jlcr.4092. Epub 2024 Apr 25. J Labelled Comp Radiopharm. 2024. PMID: 38661253
Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.
McConnell EV, Bruzual I, Pou S, Winter R, Dodean RA, Smilkstein MJ, Krollenbrock A, Nilsen A, Zakharov LN, Riscoe MK, Doggett JS. McConnell EV, et al. Among authors: nilsen a. ACS Infect Dis. 2018 Nov 9;4(11):1574-1584. doi: 10.1021/acsinfecdis.8b00133. Epub 2018 Aug 30. ACS Infect Dis. 2018. PMID: 30117728 Free PMC article.
Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, Charman SA, Zakharov LN, Bathurst I, Burrows JN, Vaidya AB, Riscoe MK. Nilsen A, et al. J Med Chem. 2014 May 8;57(9):3818-34. doi: 10.1021/jm500147k. Epub 2014 Apr 18. J Med Chem. 2014. PMID: 24720377 Free PMC article.
Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.
Frueh L, Li Y, Mather MW, Li Q, Pou S, Nilsen A, Winter RW, Forquer IP, Pershing AM, Xie LH, Smilkstein MJ, Caridha D, Koop DR, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, Kelly JX, Vesely B, Vaidya AB, Riscoe MK. Frueh L, et al. Among authors: nilsen a. ACS Infect Dis. 2017 Oct 13;3(10):728-735. doi: 10.1021/acsinfecdis.7b00062. Epub 2017 Sep 27. ACS Infect Dis. 2017. PMID: 28927276 Free PMC article.
3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.
Pou S, Winter RW, Dodean RA, Liebman K, Li Y, Mather MW, Nepal B, Nilsen A, Handford MJ, Riscoe TM, Laxson S, Kirtley PJ, Aleshnick M, Zakharov LN, Kelly JX, Smilkstein MJ, Wilder BK, Kortagere S, Vaidya AB, Alday PH, Doggett JS, Riscoe MK. Pou S, et al. Among authors: nilsen a. ACS Infect Dis. 2024 Jul 12;10(7):2419-2442. doi: 10.1021/acsinfecdis.4c00140. Epub 2024 Jun 11. ACS Infect Dis. 2024. PMID: 38862127
Long-acting intramuscular injections of ELQ-331, an antimalarial agent.
Karunakaran D, Mutyam SK, Fu M, Chen J, Pham KHN, Pou S, Winter RW, Nilsen A, Dodean RA, Smilkstein MJ, Riscoe MK, Shankar G. Karunakaran D, et al. Among authors: nilsen a. Eur J Pharm Sci. 2024 Jul 1;198:106795. doi: 10.1016/j.ejps.2024.106795. Epub 2024 May 8. Eur J Pharm Sci. 2024. PMID: 38729224 Free article.
231 results