Ebetino FH - Search Results

1

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R. Artz JD, et al. Among authors: ebetino fh. Chem Biol. 2008 Dec 22;15(12):1296-306. doi: 10.1016/j.chembiol.2008.10.017. Chem Biol. 2008. PMID: 19101474

2

Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum.

Rogers MJ, Watts DJ, Russell RG, Ji X, Xiong X, Blackburn GM, Bayless AV, Ebetino FH. Rogers MJ, et al. Among authors: ebetino fh. J Bone Miner Res. 1994 Jul;9(7):1029-39. doi: 10.1002/jbmr.5650090710. J Bone Miner Res. 1994. PMID: 7942149

3

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

Luckman SP, Coxon FP, Ebetino FH, Russell RG, Rogers MJ. Luckman SP, et al. Among authors: ebetino fh. J Bone Miner Res. 1998 Nov;13(11):1668-78. doi: 10.1359/jbmr.1998.13.11.1668. J Bone Miner Res. 1998. PMID: 9797474 Free article.

4

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ. Dunford JE, et al. Among authors: ebetino fh. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42. J Pharmacol Exp Ther. 2001. PMID: 11160603

5

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Coxon FP, Helfrich MH, Larijani B, Muzylak M, Dunford JE, Marshall D, McKinnon AD, Nesbitt SA, Horton MA, Seabra MC, Ebetino FH, Rogers MJ. Coxon FP, et al. Among authors: ebetino fh. J Biol Chem. 2001 Dec 21;276(51):48213-22. doi: 10.1074/jbc.M106473200. Epub 2001 Oct 1. J Biol Chem. 2001. PMID: 11581260 Free article.

6

Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.

Thompson K, Dunford JE, Ebetino FH, Rogers MJ. Thompson K, et al. Among authors: ebetino fh. Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73. doi: 10.1006/bbrc.2001.6289. Biochem Biophys Res Commun. 2002. PMID: 11785983

7

Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells.

Roelofs AJ, Hulley PA, Meijer A, Ebetino FH, Russell RG, Shipman CM. Roelofs AJ, et al. Among authors: ebetino fh. Int J Cancer. 2006 Sep 15;119(6):1254-61. doi: 10.1002/ijc.21977. Int J Cancer. 2006. PMID: 16619218

8

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U. Kavanagh KL, et al. Among authors: ebetino fh. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. doi: 10.1073/pnas.0601643103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684881 Free PMC article.

9

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

Dunford JE, Rogers MJ, Ebetino FH, Phipps RJ, Coxon FP. Dunford JE, et al. Among authors: ebetino fh. J Bone Miner Res. 2006 May;21(5):684-94. doi: 10.1359/jbmr.060118. J Bone Miner Res. 2006. PMID: 16734383 Free article.

10

Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Roelofs AJ, Edwards CM, Russell RG, Ebetino FH, Rogers MJ, Hulley PA. Roelofs AJ, et al. Among authors: ebetino fh. J Pharmacol Exp Ther. 2007 Jul;322(1):228-35. doi: 10.1124/jpet.106.116467. Epub 2007 Apr 5. J Pharmacol Exp Ther. 2007. PMID: 17412884 Free PMC article.

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