Dunford JE - Search Results

1

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R. Artz JD, et al. Among authors: dunford je. Chem Biol. 2008 Dec 22;15(12):1296-306. doi: 10.1016/j.chembiol.2008.10.017. Chem Biol. 2008. PMID: 19101474

2

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ. Dunford JE, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42. J Pharmacol Exp Ther. 2001. PMID: 11160603

3

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Coxon FP, Helfrich MH, Larijani B, Muzylak M, Dunford JE, Marshall D, McKinnon AD, Nesbitt SA, Horton MA, Seabra MC, Ebetino FH, Rogers MJ. Coxon FP, et al. Among authors: dunford je. J Biol Chem. 2001 Dec 21;276(51):48213-22. doi: 10.1074/jbc.M106473200. Epub 2001 Oct 1. J Biol Chem. 2001. PMID: 11581260 Free article.

4

Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.

Thompson K, Dunford JE, Ebetino FH, Rogers MJ. Thompson K, et al. Among authors: dunford je. Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73. doi: 10.1006/bbrc.2001.6289. Biochem Biophys Res Commun. 2002. PMID: 11785983

5

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U. Kavanagh KL, et al. Among authors: dunford je. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. doi: 10.1073/pnas.0601643103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684881 Free PMC article.

6

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

Kavanagh KL, Dunford JE, Bunkoczi G, Russell RGG, Oppermann U. Kavanagh KL, et al. Among authors: dunford je. J Biol Chem. 2006 Aug 4;281(31):22004-22012. doi: 10.1074/jbc.M602603200. Epub 2006 May 11. J Biol Chem. 2006. PMID: 16698791 Free article.

7

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

Dunford JE, Rogers MJ, Ebetino FH, Phipps RJ, Coxon FP. Dunford JE, et al. J Bone Miner Res. 2006 May;21(5):684-94. doi: 10.1359/jbmr.060118. J Bone Miner Res. 2006. PMID: 16734383 Free article.

8

Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.

Marma MS, Xia Z, Stewart C, Coxon F, Dunford JE, Baron R, Kashemirov BA, Ebetino FH, Triffitt JT, Russell RG, McKenna CE. Marma MS, et al. Among authors: dunford je. J Med Chem. 2007 Nov 29;50(24):5967-75. doi: 10.1021/jm0702884. Epub 2007 Nov 2. J Med Chem. 2007. PMID: 17975902

9

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Russell RG, et al. Among authors: dunford je. Ann N Y Acad Sci. 2007 Nov;1117:209-57. doi: 10.1196/annals.1402.089. Ann N Y Acad Sci. 2007. PMID: 18056045 Review.

10

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Dunford JE, Kwaasi AA, Rogers MJ, Barnett BL, Ebetino FH, Russell RG, Oppermann U, Kavanagh KL. Dunford JE, et al. J Med Chem. 2008 Apr 10;51(7):2187-95. doi: 10.1021/jm7015733. Epub 2008 Mar 8. J Med Chem. 2008. PMID: 18327899

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