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Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice.
Stoddart CA, Nault G, Galkina SA, Thibaudeau K, Bakis P, Bousquet-Gagnon N, Robitaille M, Bellomo M, Paradis V, Liscourt P, Lobach A, Rivard ME, Ptak RG, Mankowski MK, Bridon D, Quraishi O. Stoddart CA, et al. Among authors: mankowski mk. J Biol Chem. 2008 Dec 5;283(49):34045-52. doi: 10.1074/jbc.M805536200. Epub 2008 Sep 22. J Biol Chem. 2008. PMID: 18809675 Free PMC article.
Potent strategy to inhibit HIV-1 by binding both gp120 and gp41.
Kagiampakis I, Gharibi A, Mankowski MK, Snyder BA, Ptak RG, Alatas K, LiWang PJ. Kagiampakis I, et al. Among authors: mankowski mk. Antimicrob Agents Chemother. 2011 Jan;55(1):264-75. doi: 10.1128/AAC.00376-10. Epub 2010 Oct 18. Antimicrob Agents Chemother. 2011. PMID: 20956603 Free PMC article.
An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.
Bennett RP, Stewart RA, Hogan PA, Ptak RG, Mankowski MK, Hartman TL, Buckheit RW Jr, Snyder BA, Salter JD, Morales GA, Smith HC. Bennett RP, et al. Among authors: mankowski mk. Antiviral Res. 2016 Dec;136:51-59. doi: 10.1016/j.antiviral.2016.11.001. Epub 2016 Nov 5. Antiviral Res. 2016. PMID: 27825797 Free PMC article.
Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.
Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, Cocklin S. Tuyishime M, et al. Among authors: mankowski mk. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5439-45. doi: 10.1016/j.bmcl.2014.10.027. Bioorg Med Chem Lett. 2014. PMID: 25454268 Free PMC article.
Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.
Lackman-Smith C, Osterling C, Luckenbaugh K, Mankowski M, Snyder B, Lewis G, Paull J, Profy A, Ptak RG, Buckheit RW Jr, Watson KM, Cummins JE Jr, Sanders-Beer BE. Lackman-Smith C, et al. Antimicrob Agents Chemother. 2008 May;52(5):1768-81. doi: 10.1128/AAC.01328-07. Epub 2008 Mar 3. Antimicrob Agents Chemother. 2008. PMID: 18316528 Free PMC article.
25 results