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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Zhong Z, et al. Among authors: thiyagarajan m. J Clin Invest. 2009 Nov;119(11):3437-49. doi: 10.1172/JCI38476. Epub 2009 Oct 19. J Clin Invest. 2009. PMID: 19841542 Free PMC article.
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Cheng T, et al. Among authors: thiyagarajan m. Nat Med. 2006 Nov;12(11):1278-85. doi: 10.1038/nm1498. Epub 2006 Oct 29. Nat Med. 2006. PMID: 17072311
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.
Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. Deane R, et al. Among authors: thiyagarajan m. J Clin Invest. 2012 Apr;122(4):1377-92. doi: 10.1172/JCI58642. Epub 2012 Mar 12. J Clin Invest. 2012. PMID: 22406537 Free PMC article.
Sleep drives metabolite clearance from the adult brain.
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M. Xie L, et al. Among authors: thiyagarajan m. Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224. Science. 2013. PMID: 24136970 Free PMC article.
55 results