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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
Murray JK, Qian YX, Liu B, Elliott R, Aral J, Park C, Zhang X, Stenkilsson M, Salyers K, Rose M, Li H, Yu S, Andrews KL, Colombero A, Werner J, Gaida K, Sickmier EA, Miu P, Itano A, McGivern J, Gegg CV, Sullivan JK, Miranda LP. Murray JK, et al. Among authors: gegg cv. J Med Chem. 2015 Sep 10;58(17):6784-802. doi: 10.1021/acs.jmedchem.5b00495. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26288216
Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G-Protein-Coupled Receptor.
King CT, Gegg CV, Hu SN, Sen Lu H, Chan BM, Berry KA, Brankow DW, Boone TJ, Kezunovic N, Kelley MR, Shi L, Xu C. King CT, et al. Among authors: gegg cv. ACS Pharmacol Transl Sci. 2019 Sep 3;2(6):485-490. doi: 10.1021/acsptsci.9b00061. eCollection 2019 Dec 13. ACS Pharmacol Transl Sci. 2019. PMID: 32259079 Free PMC article.
Mono-N-terminal poly(ethylene glycol)-protein conjugates.
Kinstler O, Molineux G, Treuheit M, Ladd D, Gegg C. Kinstler O, et al. Adv Drug Deliv Rev. 2002 Jun 17;54(4):477-85. doi: 10.1016/s0169-409x(02)00023-6. Adv Drug Deliv Rev. 2002. PMID: 12052710 Review.
18 results