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An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation.
Byrne FR, Winters A, Brankow D, Hu S, Juan T, Steavenson S, Doellgast G, Kuchimanchi K, Brown H, Anderson S, Smelt S, Sullivan T, Alcorn D, Tocker J, Dean C Jr, Macmaster J, Kirchner J, Buys J, Manoukian R, Jiao E, Zou X, Campanella GS, Siu G. Byrne FR, et al. Among authors: doellgast g. Autoimmunity. 2009 Mar;42(3):171-82. doi: 10.1080/08916930802629547. Autoimmunity. 2009. PMID: 19301198 Free article.
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength.
Ominsky MS, Vlasseros F, Jolette J, Smith SY, Stouch B, Doellgast G, Gong J, Gao Y, Cao J, Graham K, Tipton B, Cai J, Deshpande R, Zhou L, Hale MD, Lightwood DJ, Henry AJ, Popplewell AG, Moore AR, Robinson MK, Lacey DL, Simonet WS, Paszty C. Ominsky MS, et al. Among authors: doellgast g. J Bone Miner Res. 2010 May;25(5):948-59. doi: 10.1002/jbmr.14. J Bone Miner Res. 2010. PMID: 20200929 Free article.
Monoclonal antibodies to B and T lymphocyte attenuator (BTLA) have no effect on in vitro B cell proliferation and act to inhibit in vitro T cell proliferation when presented in a cis, but not trans, format relative to the activating stimulus.
Zhang M, Howard K, Winters A, Steavenson S, Anderson S, Smelt S, Doellgast G, Sheelo C, Stevens J, Kim H, Hamburger A, Sein A, Caughey DJ, Lee F, Hsu H, Siu G, Byrne FR. Zhang M, et al. Among authors: doellgast g. Clin Exp Immunol. 2011 Jan;163(1):77-87. doi: 10.1111/j.1365-2249.2010.04259.x. Epub 2010 Nov 16. Clin Exp Immunol. 2011. PMID: 21078085 Free PMC article.
63 results