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Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Filosa R, Carmela Fulco M, Marinozzi M, Giacchè N, Macchiarulo A, Peduto A, Massa A, de Caprariis P, Thomsen C, Christoffersen CT, Pellicciari R. Filosa R, et al. Among authors: christoffersen ct. Bioorg Med Chem. 2009 Jan 1;17(1):242-50. doi: 10.1016/j.bmc.2008.11.015. Epub 2008 Nov 14. Bioorg Med Chem. 2009. PMID: 19042134
Synthesis and SAR study of a novel series of dopamine receptor agonists.
Risgaard R, Jensen M, Jørgensen M, Bang-Andersen B, Christoffersen CT, Jensen KG, Kristensen JL, Püschl A. Risgaard R, et al. Among authors: christoffersen ct. Bioorg Med Chem. 2014 Jan 1;22(1):381-92. doi: 10.1016/j.bmc.2013.11.012. Epub 2013 Nov 15. Bioorg Med Chem. 2014. PMID: 24296012
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.
Sams AG, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B. Sams AG, et al. Among authors: christoffersen ct. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5134-40. doi: 10.1016/j.bmcl.2012.05.048. Epub 2012 May 18. Bioorg Med Chem Lett. 2012. PMID: 22677319
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.
Sams AG, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B. Sams AG, et al. Among authors: christoffersen ct. J Med Chem. 2010 Sep 9;53(17):6386-97. doi: 10.1021/jm100697g. J Med Chem. 2010. PMID: 20684563
41 results