Fex M - Search Results

1

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis.

Fex M, Haemmerle G, Wierup N, Dekker-Nitert M, Rehn M, Ristow M, Zechner R, Sundler F, Holm C, Eliasson L, Mulder H. Fex M, et al. Diabetologia. 2009 Feb;52(2):271-80. doi: 10.1007/s00125-008-1191-9. Epub 2008 Nov 21. Diabetologia. 2009. PMID: 19023560

2

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact.

Mulder H, Sörhede-Winzell M, Contreras JA, Fex M, Ström K, Ploug T, Galbo H, Arner P, Lundberg C, Sundler F, Ahrén B, Holm C. Mulder H, et al. Among authors: fex m. J Biol Chem. 2003 Sep 19;278(38):36380-8. doi: 10.1074/jbc.M213032200. Epub 2003 Jun 30. J Biol Chem. 2003. PMID: 12835327 Free article.

3

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.

Ristow M, Mulder H, Pomplun D, Schulz TJ, Müller-Schmehl K, Krause A, Fex M, Puccio H, Müller J, Isken F, Spranger J, Müller-Wieland D, Magnuson MA, Möhlig M, Koenig M, Pfeiffer AF. Ristow M, et al. Among authors: fex m. J Clin Invest. 2003 Aug;112(4):527-34. doi: 10.1172/JCI18107. J Clin Invest. 2003. PMID: 12925693 Free PMC article.

4

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.

Fex M, Olofsson CS, Fransson U, Bacos K, Lindvall H, Sörhede-Winzell M, Rorsman P, Holm C, Mulder H. Fex M, et al. Endocrinology. 2004 Aug;145(8):3746-53. doi: 10.1210/en.2003-1673. Epub 2004 May 13. Endocrinology. 2004. PMID: 15142983

5

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.

Björkqvist M, Fex M, Renström E, Wierup N, Petersén A, Gil J, Bacos K, Popovic N, Li JY, Sundler F, Brundin P, Mulder H. Björkqvist M, et al. Among authors: fex m. Hum Mol Genet. 2005 Mar 1;14(5):565-74. doi: 10.1093/hmg/ddi053. Epub 2005 Jan 13. Hum Mol Genet. 2005. PMID: 15649949

6

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Fex M, Nitert MD, Wierup N, Sundler F, Ling C, Mulder H. Fex M, et al. Diabetologia. 2007 Jan;50(1):74-83. doi: 10.1007/s00125-006-0464-4. Epub 2006 Nov 9. Diabetologia. 2007. PMID: 17093947

7

Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance.

Fex M, Wierup N, Nitert MD, Ristow M, Mulder H. Fex M, et al. J Endocrinol. 2007 Sep;194(3):551-5. doi: 10.1677/JOE-07-0161. J Endocrinol. 2007. PMID: 17761894

8

Lipases in the pancreatic beta-cell: implications for insulin secretion.

Fex M, Mulder H. Fex M, et al. Biochem Soc Trans. 2008 Oct;36(Pt 5):885-90. doi: 10.1042/BST0360885. Biochem Soc Trans. 2008. PMID: 18793156 Review.

9

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M, Altshuler D, Sundler F, Eriksson JG, Jackson AU, Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L. Lyssenko V, et al. Among authors: fex m. Nat Genet. 2009 Jan;41(1):82-8. doi: 10.1038/ng.288. Epub 2008 Dec 7. Nat Genet. 2009. PMID: 19060908 Free PMC article.

10

Apelin is a novel islet peptide.

Ringström C, Nitert MD, Bennet H, Fex M, Valet P, Rehfeld JF, Friis-Hansen L, Wierup N. Ringström C, et al. Among authors: fex m. Regul Pept. 2010 Jun 8;162(1-3):44-51. doi: 10.1016/j.regpep.2010.03.005. Epub 2010 Mar 24. Regul Pept. 2010. PMID: 20346374 Free article.

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