Morgan JB - Search Results

1

Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells.

Liu Y, Liu R, Mao SC, Morgan JB, Jekabsons MB, Zhou YD, Nagle DG. Liu Y, et al. Among authors: morgan jb. J Nat Prod. 2008 Nov;71(11):1854-60. doi: 10.1021/np800342s. Epub 2008 Nov 6. J Nat Prod. 2008. PMID: 18989978 Free PMC article.

2

Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways.

Liu Y, Veena CK, Morgan JB, Mohammed KA, Jekabsons MB, Nagle DG, Zhou YD. Liu Y, et al. Among authors: morgan jb. J Biol Chem. 2009 Feb 27;284(9):5859-68. doi: 10.1074/jbc.M806744200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091749 Free PMC article.

3

Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. inhibit mitochondrial respiration and HIF-1 activation.

Mao SC, Liu Y, Morgan JB, Jekabsons MB, Zhou YD, Nagle DG. Mao SC, et al. Among authors: morgan jb. J Nat Prod. 2009 Nov;72(11):1927-36. doi: 10.1021/np900444m. J Nat Prod. 2009. PMID: 19845338 Free PMC article.

4

The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration.

Liu Y, Morgan JB, Coothankandaswamy V, Liu R, Jekabsons MB, Mahdi F, Nagle DG, Zhou YD. Liu Y, et al. Among authors: morgan jb. J Nat Prod. 2009 Dec;72(12):2104-9. doi: 10.1021/np9005794. J Nat Prod. 2009. PMID: 19921787 Free PMC article.

5

The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.

Coothankandaswamy V, Liu Y, Mao SC, Morgan JB, Mahdi F, Jekabsons MB, Nagle DG, Zhou YD. Coothankandaswamy V, et al. Among authors: morgan jb. J Nat Prod. 2010 May 28;73(5):956-61. doi: 10.1021/np100228d. J Nat Prod. 2010. PMID: 20423107 Free PMC article.

6

The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor.

Morgan JB, Mahdi F, Liu Y, Coothankandaswamy V, Jekabsons MB, Johnson TA, Sashidhara KV, Crews P, Nagle DG, Zhou YD. Morgan JB, et al. Bioorg Med Chem. 2010 Aug 15;18(16):5988-94. doi: 10.1016/j.bmc.2010.06.072. Epub 2010 Jun 25. Bioorg Med Chem. 2010. PMID: 20637638 Free PMC article.

7

Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.

Morgan JB, Liu Y, Coothankandaswamy V, Mahdi F, Jekabsons MB, Gerwick WH, Valeriote FA, Zhou YD, Nagle DG. Morgan JB, et al. Mar Drugs. 2015 Mar 20;13(3):1552-68. doi: 10.3390/md13031552. Mar Drugs. 2015. PMID: 25803180 Free PMC article.

8

Sampangine (a Copyrine Alkaloid) Exerts Biological Activities through Cellular Redox Cycling of Its Quinone and Semiquinone Intermediates.

Mahdi F, Morgan JB, Liu W, Agarwal AK, Jekabsons MB, Liu Y, Zhou YD, Nagle DG. Mahdi F, et al. Among authors: morgan jb. J Nat Prod. 2015 Dec 24;78(12):3018-23. doi: 10.1021/acs.jnatprod.5b00819. Epub 2015 Dec 4. J Nat Prod. 2015. PMID: 26637046

9

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.

Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S. Fromont C, et al. J Med Chem. 2020 Jul 9;63(13):6784-6801. doi: 10.1021/acs.jmedchem.9b01803. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32433887 Free PMC article.

10

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.

Morgan J, Saleem M, Ng R, Armstrong C, Wong SS, Caulton SG, Fickling A, Williams HEL, Munday AD, López JA, Searle MS, Emsley J. Morgan J, et al. Blood Adv. 2019 May 14;3(9):1450-1459. doi: 10.1182/bloodadvances.2018027011. Blood Adv. 2019. PMID: 31053572 Free PMC article.

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