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Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.
Kalia NP, Hasenoehrl EJ, Ab Rahman NB, Koh VH, Ang MLT, Sajorda DR, Hards K, Grüber G, Alonso S, Cook GM, Berney M, Pethe K. Kalia NP, et al. Among authors: alonso s. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7426-7431. doi: 10.1073/pnas.1706139114. Epub 2017 Jun 26. Proc Natl Acad Sci U S A. 2017. PMID: 28652330 Free PMC article.
HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.
Ngan JYG, Pasunooti S, Tse W, Meng W, Ngan SFC, Jia H, Lin JQ, Ng SW, Jaafa MT, Cho SLS, Lim J, Koh HQV, Abdul Ghani N, Pethe K, Sze SK, Lescar J, Alonso S. Ngan JYG, et al. Among authors: alonso s. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2006717118. doi: 10.1073/pnas.2006717118. Proc Natl Acad Sci U S A. 2021. PMID: 33723035 Free PMC article.
EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide.
Ang MLT, Zainul Rahim SZ, de Sessions PF, Lin W, Koh V, Pethe K, Hibberd ML, Alonso S. Ang MLT, et al. Among authors: alonso s. Front Microbiol. 2017 Apr 25;8:710. doi: 10.3389/fmicb.2017.00710. eCollection 2017. Front Microbiol. 2017. PMID: 28487681 Free PMC article.
Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.
Lee BS, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMS, Manimekalai MSS, Koh VH, Chan J, Xu J, Alonso S, Miller MJ, Steyn AJC, Grüber G, Schnappinger D, Berney M, Cook GM, Moraski GC, Pethe K. Lee BS, et al. Among authors: alonso s. EMBO Mol Med. 2021 Jan 11;13(1):e13207. doi: 10.15252/emmm.202013207. Epub 2020 Dec 7. EMBO Mol Med. 2021. PMID: 33283973 Free PMC article.
910 results