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Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Rubinstein MP, Kovar M, Purton JF, Cho JH, Boyman O, Surh CD, Sprent J. Rubinstein MP, et al. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9166-71. doi: 10.1073/pnas.0600240103. Epub 2006 Jun 6. Proc Natl Acad Sci U S A. 2006. PMID: 16757567 Free PMC article.
Antiviral CD4+ memory T cells are IL-15 dependent.
Purton JF, Tan JT, Rubinstein MP, Kim DM, Sprent J, Surh CD. Purton JF, et al. Among authors: rubinstein mp. J Exp Med. 2007 Apr 16;204(4):951-61. doi: 10.1084/jem.20061805. Epub 2007 Apr 9. J Exp Med. 2007. PMID: 17420265 Free PMC article.
IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy.
Su EW, Moore CJ, Suriano S, Johnson CB, Songalia N, Patterson A, Neitzke DJ, Andrijauskaite K, Garrett-Mayer E, Mehrotra S, Paulos CM, Doedens AL, Goldrath AW, Li Z, Cole DJ, Rubinstein MP. Su EW, et al. Among authors: rubinstein mp. Sci Transl Med. 2015 Oct 28;7(311):311ra170. doi: 10.1126/scitranslmed.aac8155. Sci Transl Med. 2015. PMID: 26511507 Free PMC article.
Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance.
Doedens AL, Rubinstein MP, Gross ET, Best JA, Craig DH, Baker MK, Cole DJ, Bui JD, Goldrath AW. Doedens AL, et al. Among authors: rubinstein mp. Cancer Immunol Res. 2016 Sep 2;4(9):799-811. doi: 10.1158/2326-6066.CIR-15-0178. Epub 2016 Aug 2. Cancer Immunol Res. 2016. PMID: 27485135 Free PMC article.
102 results