Cochran JR - Search Results

1

Developing therapeutic proteins by engineering ligand-receptor interactions.

Jones DS, Silverman AP, Cochran JR. Jones DS, et al. Among authors: cochran jr. Trends Biotechnol. 2008 Sep;26(9):498-505. doi: 10.1016/j.tibtech.2008.05.009. Epub 2008 Jul 31. Trends Biotechnol. 2008. PMID: 18675482 Review.

2

Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities.

Silverman AP, Levin AM, Lahti JL, Cochran JR. Silverman AP, et al. Among authors: cochran jr. J Mol Biol. 2009 Jan 30;385(4):1064-75. doi: 10.1016/j.jmb.2008.11.004. Epub 2008 Nov 12. J Mol Biol. 2009. PMID: 19038268 Free PMC article.

3

Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein.

Lahti JL, Silverman AP, Cochran JR. Lahti JL, et al. Among authors: cochran jr. PLoS Comput Biol. 2009 Sep;5(9):e1000499. doi: 10.1371/journal.pcbi.1000499. Epub 2009 Sep 4. PLoS Comput Biol. 2009. PMID: 19730675 Free PMC article.

4

Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu H, Li P, Gambhir SS, Cochran JR, Cheng Z. Jiang L, et al. Among authors: cochran jr. J Nucl Med. 2010 Feb;51(2):251-258. doi: 10.2967/jnumed.109.069831. J Nucl Med. 2010. PMID: 20124048 Free PMC article.

5

Engineered proteins pull double duty.

Cochran JR. Cochran JR. Sci Transl Med. 2010 Feb 3;2(17):17ps5. doi: 10.1126/scitranslmed.3000276. Sci Transl Med. 2010. PMID: 20371477 Review.

6

Cystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.

Silverman AP, Kariolis MS, Cochran JR. Silverman AP, et al. Among authors: cochran jr. J Mol Recognit. 2011 Jan-Feb;24(1):127-35. doi: 10.1002/jmr.1036. J Mol Recognit. 2011. PMID: 21194123

7

Functional mutation of multiple solvent-exposed loops in the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein.

Kimura RH, Jones DS, Jiang L, Miao Z, Cheng Z, Cochran JR. Kimura RH, et al. Among authors: cochran jr. PLoS One. 2011 Feb 18;6(2):e16112. doi: 10.1371/journal.pone.0016112. PLoS One. 2011. PMID: 21364742 Free PMC article.

8

Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists.

Jones DS 2nd, Tsai PC, Cochran JR. Jones DS 2nd, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13035-40. doi: 10.1073/pnas.1102561108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788476 Free PMC article.

9

Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin.

Papo N, Silverman AP, Lahti JL, Cochran JR. Papo N, et al. Among authors: cochran jr. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14067-72. doi: 10.1073/pnas.1016635108. Epub 2011 Aug 8. Proc Natl Acad Sci U S A. 2011. PMID: 21825147 Free PMC article.

10

111In-labeled cystine-knot peptides based on the Agouti-related protein for targeting tumor angiogenesis.

Jiang L, Miao Z, Kimura RH, Silverman AP, Ren G, Liu H, Lu H, Cochran JR, Cheng Z. Jiang L, et al. Among authors: cochran jr. J Biomed Biotechnol. 2012;2012:368075. doi: 10.1155/2012/368075. Epub 2012 Apr 11. J Biomed Biotechnol. 2012. PMID: 22570527 Free PMC article.

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