Shimohigashi Y - Search Results

1

ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner.

Matsushima A, Teramoto T, Okada H, Liu X, Tokunaga T, Kakuta Y, Shimohigashi Y. Matsushima A, et al. Among authors: shimohigashi y. Biochem Biophys Res Commun. 2008 Aug 29;373(3):408-13. doi: 10.1016/j.bbrc.2008.06.050. Epub 2008 Jun 26. Biochem Biophys Res Commun. 2008. PMID: 18582436

2

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activity.

Takayanagi S, Tokunaga T, Liu X, Okada H, Matsushima A, Shimohigashi Y. Takayanagi S, et al. Among authors: shimohigashi y. Toxicol Lett. 2006 Dec 1;167(2):95-105. doi: 10.1016/j.toxlet.2006.08.012. Epub 2006 Sep 3. Toxicol Lett. 2006. PMID: 17049190

3

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma.

Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y. Matsushima A, et al. Among authors: shimohigashi y. J Biochem. 2007 Oct;142(4):517-24. doi: 10.1093/jb/mvm158. Epub 2007 Aug 30. J Biochem. 2007. PMID: 17761695

4

Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor gamma. Chief and corroborative hydrogen bonds of the bisphenol A phenol-hydroxyl group with Arg316 and Glu275 residues.

Liu X, Matsushima A, Okada H, Tokunaga T, Isozaki K, Shimohigashi Y. Liu X, et al. Among authors: shimohigashi y. FEBS J. 2007 Dec;274(24):6340-51. doi: 10.1111/j.1742-4658.2007.06152.x. Epub 2007 Nov 12. FEBS J. 2007. PMID: 18005256 Free article.

5

Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma.

Okada H, Tokunaga T, Liu X, Takayanagi S, Matsushima A, Shimohigashi Y. Okada H, et al. Among authors: shimohigashi y. Environ Health Perspect. 2008 Jan;116(1):32-8. doi: 10.1289/ehp.10587. Environ Health Perspect. 2008. PMID: 18197296 Free PMC article.

6

Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform.

Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y. Takeda Y, et al. Among authors: shimohigashi m, shimohigashi y. J Biochem. 2009 Jul;146(1):113-22. doi: 10.1093/jb/mvp049. Epub 2009 Mar 20. J Biochem. 2009. PMID: 19304792

7

Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta.

Matsushima A, Liu X, Okada H, Shimohigashi M, Shimohigashi Y. Matsushima A, et al. Among authors: shimohigashi m, shimohigashi y. Environ Health Perspect. 2010 Sep;118(9):1267-72. doi: 10.1289/ehp.0901819. Epub 2010 Apr 28. Environ Health Perspect. 2010. PMID: 20427257 Free PMC article.

8

Distinction of the binding modes for human nuclear receptor ERRgamma between bisphenol A and 4-hydroxytamoxifen.

Liu X, Matsushima A, Okada H, Shimohigashi Y. Liu X, et al. Among authors: shimohigashi y. J Biochem. 2010 Aug;148(2):247-54. doi: 10.1093/jb/mvq056. Epub 2010 Jun 11. J Biochem. 2010. PMID: 20542892

9

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor estrogen-related receptor γ.

Liu X, Matsushima A, Nakamura M, Costa T, Nose T, Shimohigashi Y. Liu X, et al. Among authors: shimohigashi y. J Biochem. 2012 Apr;151(4):403-15. doi: 10.1093/jb/mvs008. Epub 2012 Jan 31. J Biochem. 2012. PMID: 22298789

10

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ.

Liu X, Matsushima A, Shimohigashi M, Shimohigashi Y. Liu X, et al. Among authors: shimohigashi m, shimohigashi y. PLoS One. 2014 Jun 30;9(6):e101252. doi: 10.1371/journal.pone.0101252. eCollection 2014. PLoS One. 2014. PMID: 24978476 Free PMC article.

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