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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Opazo C, et al. Among authors: masters cl. J Biol Chem. 2002 Oct 25;277(43):40302-8. doi: 10.1074/jbc.M206428200. Epub 2002 Aug 20. J Biol Chem. 2002. PMID: 12192006 Free article.
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R. Barnham KJ, et al. Among authors: masters cl. J Biol Chem. 2003 May 9;278(19):17401-7. doi: 10.1074/jbc.M300629200. Epub 2003 Feb 28. J Biol Chem. 2003. PMID: 12611883 Free article.
Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.
White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R. White AR, et al. Among authors: masters cl. Brain Res. 2003 Mar 21;966(2):231-44. doi: 10.1016/s0006-8993(02)04173-2. Brain Res. 2003. PMID: 12618346
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. Among authors: masters cl. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530 Free article.
1,003 results