Stewart KD - Search Results

1

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.

Gracias V, Ji Z, Akritopoulou-Zanze I, Abad-Zapatero C, Huth JR, Song D, Hajduk PJ, Johnson EF, Glaser KB, Marcotte PA, Pease L, Soni NB, Stewart KD, Davidsen SK, Michaelides MR, Djuric SW. Gracias V, et al. Among authors: stewart kd. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2691-5. doi: 10.1016/j.bmcl.2008.03.021. Epub 2008 Mar 10. Bioorg Med Chem Lett. 2008. PMID: 18362070

2

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.

Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: stewart kd. J Med Chem. 1996 Jan 19;39(2):392-7. doi: 10.1021/jm9507183. J Med Chem. 1996. PMID: 8558507

3

Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents.

Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Stewart K, Navaza J, Payne CD, Ray TL. Abad-Zapatero C, et al. Protein Sci. 1996 Apr;5(4):640-52. doi: 10.1002/pro.5560050408. Protein Sci. 1996. PMID: 8845753 Free PMC article.

4

Structure of secreted aspartic proteinases from Candida. Implications for the design of antifungal agents.

Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Oie T, Stewart K, Cutfield SM, Cutfield JF, Foundling SI, Ray TL. Abad-Zapatero C, et al. Adv Exp Med Biol. 1998;436:297-313. doi: 10.1007/978-1-4615-5373-1_41. Adv Exp Med Biol. 1998. PMID: 9561233 Review.

5

Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.

Stewart KD, Loren S, Frey L, Otis E, Klinghofer V, Hulkower KI. Stewart KD, et al. Bioorg Med Chem Lett. 1998 Mar 3;8(5):529-34. doi: 10.1016/s0960-894x(98)00068-7. Bioorg Med Chem Lett. 1998. PMID: 9871612

6

The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.

Schluckebier G, Zhong P, Stewart KD, Kavanaugh TJ, Abad-Zapatero C. Schluckebier G, et al. Among authors: stewart kd. J Mol Biol. 1999 Jun 4;289(2):277-91. doi: 10.1006/jmbi.1999.2788. J Mol Biol. 1999. PMID: 10366505

7

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG. Wang GT, et al. J Med Chem. 2001 Apr 12;44(8):1192-201. doi: 10.1021/jm000468c. J Med Chem. 2001. PMID: 11312919

8

Candida proteases and their inhibition: prospects for antifungal therapy.

Stewart K, Abad-Zapatero C. Stewart K, et al. Curr Med Chem. 2001 Jul;8(8):941-8. doi: 10.2174/0929867013372698. Curr Med Chem. 2001. PMID: 11375761 Review.

9

X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease.

Stoll V, Qin W, Stewart KD, Jakob C, Park C, Walter K, Simmer RL, Helfrich R, Bussiere D, Kao J, Kempf D, Sham HL, Norbeck DW. Stoll V, et al. Among authors: stewart kd. Bioorg Med Chem. 2002 Aug;10(8):2803-6. doi: 10.1016/s0968-0896(02)00051-2. Bioorg Med Chem. 2002. PMID: 12057670

10

Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm.

Hanessian S, Wang J, Montgomery D, Stoll V, Stewart KD, Kati W, Maring C, Kempf D, Hutchins C, Laver WG. Hanessian S, et al. Among authors: stewart kd. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3425-9. doi: 10.1016/s0960-894x(02)00732-1. Bioorg Med Chem Lett. 2002. PMID: 12419376

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