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Page 1
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, Flynn JL, Barry CE 3rd. Via LE, et al. Among authors: manjunatha u. Infect Immun. 2008 Jun;76(6):2333-40. doi: 10.1128/IAI.01515-07. Epub 2008 Mar 17. Infect Immun. 2008. PMID: 18347040 Free PMC article.
Mycobacterium leprae is naturally resistant to PA-824.
Manjunatha UH, Lahiri R, Randhawa B, Dowd CS, Krahenbuhl JL, Barry CE 3rd. Manjunatha UH, et al. Antimicrob Agents Chemother. 2006 Oct;50(10):3350-4. doi: 10.1128/AAC.00488-06. Antimicrob Agents Chemother. 2006. PMID: 17005816 Free PMC article.
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Singh R, Manjunatha U, Boshoff HI, Ha YH, Niyomrattanakit P, Ledwidge R, Dowd CS, Lee IY, Kim P, Zhang L, Kang S, Keller TH, Jiricek J, Barry CE 3rd. Singh R, et al. Among authors: manjunatha u. Science. 2008 Nov 28;322(5906):1392-5. doi: 10.1126/science.1164571. Science. 2008. PMID: 19039139 Free PMC article.
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS. Kim P, et al. J Med Chem. 2006 Jan 12;49(1):159-71. doi: 10.1021/jm050825p. J Med Chem. 2006. PMID: 16392800 Free PMC article.
52 results