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Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.
Rabionet M, van der Spoel AC, Chuang CC, von Tümpling-Radosta B, Litjens M, Bouwmeester D, Hellbusch CC, Körner C, Wiegandt H, Gorgas K, Platt FM, Gröne HJ, Sandhoff R. Rabionet M, et al. Among authors: platt fm. J Biol Chem. 2008 May 9;283(19):13357-69. doi: 10.1074/jbc.M800870200. Epub 2008 Feb 27. J Biol Chem. 2008. PMID: 18308723 Free PMC article.
Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.
Porubsky S, Speak AO, Salio M, Jennemann R, Bonrouhi M, Zafarulla R, Singh Y, Dyson J, Luckow B, Lehuen A, Malle E, Müthing J, Platt FM, Cerundolo V, Gröne HJ. Porubsky S, et al. Among authors: platt fm. J Immunol. 2012 Sep 15;189(6):3007-17. doi: 10.4049/jimmunol.1201483. Epub 2012 Aug 8. J Immunol. 2012. PMID: 22875802 Free PMC article.
β-Glucosidase 2 (GBA2) activity and imino sugar pharmacology.
Ridley CM, Thur KE, Shanahan J, Thillaiappan NB, Shen A, Uhl K, Walden CM, Rahim AA, Waddington SN, Platt FM, van der Spoel AC. Ridley CM, et al. Among authors: platt fm. J Biol Chem. 2013 Sep 6;288(36):26052-26066. doi: 10.1074/jbc.M113.463562. Epub 2013 Jul 23. J Biol Chem. 2013. PMID: 23880767 Free PMC article.
TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.
Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, Trottein F. Paget C, et al. Among authors: platt fm. PLoS Biol. 2019 Mar 1;17(3):e3000169. doi: 10.1371/journal.pbio.3000169. eCollection 2019 Mar. PLoS Biol. 2019. PMID: 30822302 Free PMC article.
259 results