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Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Schroeder GM, Chen XT, Williams DK, Nirschl DS, Cai ZW, Wei D, Tokarski JS, An Y, Sack J, Chen Z, Huynh T, Vaccaro W, Poss M, Wautlet B, Gullo-Brown J, Kellar K, Manne V, Hunt JT, Wong TW, Lombardo LJ, Fargnoli J, Borzilleri RM. Schroeder GM, et al. Among authors: chen z, chen xt. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1945-51. doi: 10.1016/j.bmcl.2008.01.121. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18289854
Pyrrolopyridazine MEK inhibitors.
Chen Z, Kim SH, Barbosa SA, Huynh T, Tortolani DR, Leavitt KJ, Wei DD, Manne V, Ricca CS, Gullo-Brown J, Poss MA, Vaccaro W, Salvati ME. Chen Z, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):628-32. doi: 10.1016/j.bmcl.2005.10.052. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275076
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.
Tarby CM, Kaltenbach RF 3rd, Huynh T, Pudzianowski A, Shen H, Ortega-Nanos M, Sheriff S, Newitt JA, McDonnell PA, Burford N, Fairchild CR, Vaccaro W, Chen Z, Borzilleri RM, Naglich J, Lombardo LJ, Gottardis M, Trainor GL, Roussell DL. Tarby CM, et al. Among authors: chen z. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2095-100. doi: 10.1016/j.bmcl.2006.01.056. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458511
Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).
Huynh T, Chen Z, Pang S, Geng J, Bandiera T, Bindi S, Vianello P, Roletto F, Thieffine S, Galvani A, Vaccaro W, Poss MA, Trainor GL, Lorenzi MV, Gottardis M, Jayaraman L, Purandare AV. Huynh T, et al. Among authors: chen z. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2924-7. doi: 10.1016/j.bmcl.2009.04.075. Epub 2009 Apr 22. Bioorg Med Chem Lett. 2009. PMID: 19419866
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
McDonnell PA, Yanchunas J, Newitt JA, Tao L, Kiefer SE, Ortega M, Kut S, Burford N, Goldfarb V, Duke GJ, Shen H, Metzler W, Doyle M, Chen Z, Tarby C, Borzilleri R, Vaccaro W, Gottardis M, Lu S, Crews D, Kim K, Lombardo L, Roussell DL. McDonnell PA, et al. Among authors: chen z. Anal Biochem. 2009 Sep 1;392(1):59-69. doi: 10.1016/j.ab.2009.05.044. Epub 2009 Jun 2. Anal Biochem. 2009. PMID: 19497292
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