Fernández A - Search Results

1

Induced disorder in protein-ligand complexes as a drug-design strategy.

Crespo A, Fernández A. Crespo A, et al. Among authors: fernandez a. Mol Pharm. 2008 May-Jun;5(3):430-7. doi: 10.1021/mp700148h. Epub 2008 Feb 16. Mol Pharm. 2008. PMID: 18278867

2

Kinase packing defects as drug targets.

Crespo A, Fernández A. Crespo A, et al. Among authors: fernandez a. Drug Discov Today. 2007 Nov;12(21-22):917-23. doi: 10.1016/j.drudis.2007.09.009. Epub 2007 Oct 30. Drug Discov Today. 2007. PMID: 17993409 Free PMC article. Review.

3

An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic.

Fernández A, Sanguino A, Peng Z, Ozturk E, Chen J, Crespo A, Wulf S, Shavrin A, Qin C, Ma J, Trent J, Lin Y, Han HD, Mangala LS, Bankson JA, Gelovani J, Samarel A, Bornmann W, Sood AK, Lopez-Berestein G. Fernández A, et al. J Clin Invest. 2007 Dec;117(12):4044-54. doi: 10.1172/JCI32373. J Clin Invest. 2007. PMID: 18060038 Free PMC article.

4

Protein wrapping: a molecular marker for association, aggregation and drug design.

Fernández A, Crespo A. Fernández A, et al. Chem Soc Rev. 2008 Nov;37(11):2373-82. doi: 10.1039/b804150b. Epub 2008 Sep 15. Chem Soc Rev. 2008. PMID: 18949110 Review.

5

Rational drug redesign to overcome drug resistance in cancer therapy: imatinib moving target.

Fernández A, Sanguino A, Peng Z, Crespo A, Ozturk E, Zhang X, Wang S, Bornmann W, Lopez-Berestein G. Fernández A, et al. Cancer Res. 2007 May 1;67(9):4028-33. doi: 10.1158/0008-5472.CAN-07-0345. Cancer Res. 2007. PMID: 17483313 Free PMC article.

6

Passive water-lipid peptide translocators with conformational switches: from single-molecule probe to cellular assay.

Fernández A, Crespo A, Blau A. Fernández A, et al. J Phys Chem B. 2007 Dec 20;111(50):13987-92. doi: 10.1021/jp074479u. Epub 2007 Nov 29. J Phys Chem B. 2007. PMID: 18044863 Free PMC article.

7

Turning promiscuous kinase inhibitors into safer drugs.

Zhang X, Crespo A, Fernández A. Zhang X, et al. Among authors: fernandez a. Trends Biotechnol. 2008 Jun;26(6):295-301. doi: 10.1016/j.tibtech.2008.02.008. Epub 2008 Apr 9. Trends Biotechnol. 2008. PMID: 18403035 Review.

8

Redesigning kinase inhibitors to enhance specificity.

Crespo A, Zhang X, Fernández A. Crespo A, et al. Among authors: fernandez a. J Med Chem. 2008 Aug 28;51(16):4890-8. doi: 10.1021/jm800453a. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680272

9

Is there a case for selectively promiscuous anticancer drugs?

Fernández A, Crespo A, Tiwari A. Fernández A, et al. Drug Discov Today. 2009 Jan;14(1-2):1-5. doi: 10.1016/j.drudis.2008.10.008. Epub 2008 Dec 10. Drug Discov Today. 2009. PMID: 19038361

10

Bottom-up engineering of peptide cell translocators based on environmentally modulated quadrupole switches.

Fernández A, Crespo A, Maddipati S, Scott R. Fernández A, et al. ACS Nano. 2008 Jan;2(1):61-8. doi: 10.1021/nn700239j. ACS Nano. 2008. PMID: 19206548

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