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Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents.
Scherer D, Hassel D, Bloehs R, Zitron E, von Löwenstern K, Seyler C, Thomas D, Konrad F, Bürgers HF, Seemann G, Rottbauer W, Katus HA, Karle CA, Scholz EP. Scherer D, et al. Among authors: seemann g. Br J Pharmacol. 2009 Jan;156(2):226-36. doi: 10.1111/j.1476-5381.2008.00018.x. Epub 2009 Jan 16. Br J Pharmacol. 2009. PMID: 19154426 Free PMC article.
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.
Scholz EP, Konrad FM, Weiss DL, Zitron E, Kiesecker C, Bloehs R, Kulzer M, Thomas D, Kathöfer S, Bauer A, Maurer MH, Seemann G, Katus HA, Karle CA. Scholz EP, et al. Among authors: seemann g. Naunyn Schmiedebergs Arch Pharmacol. 2007 Dec;376(4):275-84. doi: 10.1007/s00210-007-0202-6. Epub 2007 Oct 27. Naunyn Schmiedebergs Arch Pharmacol. 2007. PMID: 17965852
Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K+ Channel-Related Acid-Sensitive K+ Channel-1) (K2P3.1) K+ Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling.
Schmidt C, Wiedmann F, Beyersdorf C, Zhao Z, El-Battrawy I, Lan H, Szabo G, Li X, Lang S, Korkmaz-Icöz S, Rapti K, Jungmann A, Ratte A, Müller OJ, Karck M, Seemann G, Akin I, Borggrefe M, Zhou XB, Katus HA, Thomas D. Schmidt C, et al. Among authors: seemann g. Circ Arrhythm Electrophysiol. 2019 Sep;12(9):e007465. doi: 10.1161/CIRCEP.119.007465. Epub 2019 Sep 13. Circ Arrhythm Electrophysiol. 2019. PMID: 31514528
Modeling of IK1 mutations in human left ventricular myocytes and tissue.
Seemann G, Sachse FB, Weiss DL, Ptácek LJ, Tristani-Firouzi M. Seemann G, et al. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H549-59. doi: 10.1152/ajpheart.00701.2006. Epub 2006 Aug 25. Am J Physiol Heart Circ Physiol. 2007. PMID: 16936001 Free article.
136 results