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The proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 stimulate neuropeptide gene transcription and secretion in adrenochromaffin cells via activation of extracellularly regulated kinase 1/2 and p38 protein kinases, and activator protein-1 transcription factors.
Ait-Ali D, Turquier V, Grumolato L, Yon L, Jourdain M, Alexandre D, Eiden LE, Vaudry H, Anouar Y. Ait-Ali D, et al. Mol Endocrinol. 2004 Jul;18(7):1721-39. doi: 10.1210/me.2003-0129. Epub 2004 Apr 15. Mol Endocrinol. 2004. PMID: 15087472
Tumor necrosis factor (TNF)-alpha persistently activates nuclear factor-kappaB signaling through the type 2 TNF receptor in chromaffin cells: implications for long-term regulation of neuropeptide gene expression in inflammation.
Ait-Ali D, Turquier V, Tanguy Y, Thouënnon E, Ghzili H, Mounien L, Derambure C, Jégou S, Salier JP, Vaudry H, Eiden LE, Anouar Y. Ait-Ali D, et al. Endocrinology. 2008 Jun;149(6):2840-52. doi: 10.1210/en.2007-1192. Epub 2008 Feb 21. Endocrinology. 2008. PMID: 18292192 Free PMC article.
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