Cowan SR - Search Results

1

Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.

Frederickson M, Callaghan O, Chessari G, Congreve M, Cowan SR, Matthews JE, McMenamin R, Smith DM, Vinković M, Wallis NG. Frederickson M, et al. Among authors: cowan sr. J Med Chem. 2008 Jan 24;51(2):183-6. doi: 10.1021/jm701359z. Epub 2007 Dec 29. J Med Chem. 2008. PMID: 18163548

2

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Congreve M, Aharony D, Albert J, Callaghan O, Campbell J, Carr RA, Chessari G, Cowan S, Edwards PD, Frederickson M, McMenamin R, Murray CW, Patel S, Wallis N. Congreve M, et al. J Med Chem. 2007 Mar 22;50(6):1124-32. doi: 10.1021/jm061197u. Epub 2007 Feb 22. J Med Chem. 2007. PMID: 17315857

3

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

Murray CW, Carr MG, Callaghan O, Chessari G, Congreve M, Cowan S, Coyle JE, Downham R, Figueroa E, Frederickson M, Graham B, McMenamin R, O'Brien MA, Patel S, Phillips TR, Williams G, Woodhead AJ, Woolford AJ. Murray CW, et al. J Med Chem. 2010 Aug 26;53(16):5942-55. doi: 10.1021/jm100059d. J Med Chem. 2010. PMID: 20718493

4

X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.

St Denis JD, Chessari G, Cleasby A, Cons BD, Cowan S, Dalton SE, East C, Murray CW, O'Reilly M, Peakman T, Rapti M, Stow JL. St Denis JD, et al. J Med Chem. 2022 Sep 22;65(18):12319-12333. doi: 10.1021/acs.jmedchem.2c01044. Epub 2022 Sep 13. J Med Chem. 2022. PMID: 36101934

5

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, Cao Q, Castaldi MP, Chen H, Chiarparin E, Carbajo RJ, Code E, Cowan S, Davey PR, Ferguson AD, Fillery S, Fuller NO, Gao N, Hargreaves D, Howard MR, Hu J, Kawatkar A, Kemmitt PD, Leo E, Molina DM, O'Connell N, Petteruti P, Rasmusson T, Raubo P, Rawlins PB, Ricchiuto P, Robb GR, Schenone M, Waring MJ, Zinda M, Fawell S, Wilson DM. McCoull W, et al. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141. doi: 10.1021/acschembio.8b00698. Epub 2018 Oct 17. ACS Chem Biol. 2018. PMID: 30335946

6

Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay.

Shaw J, Leveridge M, Norling C, Karén J, Molina DM, O'Neill D, Dowling JE, Davey P, Cowan S, Dabrowski M, Main M, Gianni D. Shaw J, et al. Sci Rep. 2018 Jan 9;8(1):163. doi: 10.1038/s41598-017-18650-x. Sci Rep. 2018. PMID: 29317749 Free PMC article.

7

Combination Antiretroviral Therapy and Immunophenotype of Feline Immunodeficiency Virus.

Kim J, Behzadi ES, Nehring M, Carver S, Cowan SR, Conry MK, Rawlinson JE, VandeWoude S, Miller CA. Kim J, et al. Among authors: cowan sr. Viruses. 2023 Mar 24;15(4):822. doi: 10.3390/v15040822. Viruses. 2023. PMID: 37112803 Free PMC article.

8

A Novel Vaccine Strategy to Prevent Cytauxzoonosis in Domestic Cats.

Weerarathne P, Maker R, Huang C, Taylor B, Cowan SR, Hyatt J, Tamil Selvan M, Shatnawi S, Thomas JE, Meinkoth JH, Scimeca R, Birkenheuer A, Liu L, Reichard MV, Miller CA. Weerarathne P, et al. Among authors: cowan sr. Vaccines (Basel). 2023 Mar 2;11(3):573. doi: 10.3390/vaccines11030573. Vaccines (Basel). 2023. PMID: 36992157 Free PMC article.

9

A Serodiagnostic IgM ELISA to Detect Acute Cytauxzoonosis.

Kao YF, Spainhour R, Cowan SR, Nafe L, Birkenheuer A, Reichard MV, Miller CA. Kao YF, et al. Among authors: cowan sr. Pathogens. 2022 Oct 14;11(10):1183. doi: 10.3390/pathogens11101183. Pathogens. 2022. PMID: 36297239 Free PMC article.

10

SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic Cats.

Tamil Selvan M, Gunasekara S, Xiao P, Griffin K, Cowan SR, Narayanan S, Ramachandran A, Hagen DE, Ritchey JW, Rudd JM, Miller CA. Tamil Selvan M, et al. Among authors: cowan sr. Viruses. 2022 Jun 1;14(6):1207. doi: 10.3390/v14061207. Viruses. 2022. PMID: 35746678 Free PMC article.

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