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Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses.
Harrop R, Drury N, Shingler W, Chikoti P, Redchenko I, Carroll MW, Kingsman SM, Naylor S, Griffiths R, Steven N, Hawkins RE. Harrop R, et al. Among authors: naylor s. Cancer Immunol Immunother. 2008 Jul;57(7):977-86. doi: 10.1007/s00262-007-0428-7. Cancer Immunol Immunother. 2008. PMID: 18060404 Free PMC article. Clinical Trial.
Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses.
Harrop R, Drury N, Shingler W, Chikoti P, Redchenko I, Carroll MW, Kingsman SM, Naylor S, Melcher A, Nicholls J, Wassan H, Habib N, Anthoney A. Harrop R, et al. Among authors: naylor s. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4487-94. doi: 10.1158/1078-0432.CCR-07-0704. Clin Cancer Res. 2007. PMID: 17671134 Clinical Trial.
MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients.
Harrop R, Shingler WH, McDonald M, Treasure P, Amato RJ, Hawkins RE, Kaufman HL, de Belin J, Kelleher M, Goonewardena M, Naylor S. Harrop R, et al. Among authors: naylor s. Cancer Immunol Immunother. 2011 Jun;60(6):829-37. doi: 10.1007/s00262-011-0993-7. Epub 2011 Mar 9. Cancer Immunol Immunother. 2011. PMID: 21387109 Free PMC article. Clinical Trial.
Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): a phase 2 trial.
Amato RJ, Shingler W, Goonewardena M, de Belin J, Naylor S, Jac J, Willis J, Saxena S, Hernandez-McClain J, Harrop R. Amato RJ, et al. Among authors: naylor s. J Immunother. 2009 Sep;32(7):765-72. doi: 10.1097/CJI.0b013e3181ace876. J Immunother. 2009. PMID: 19561532 Clinical Trial.
520 results