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CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.
Piva R, Ruggeri B, Williams M, Costa G, Tamagno I, Ferrero D, Giai V, Coscia M, Peola S, Massaia M, Pezzoni G, Allievi C, Pescalli N, Cassin M, di Giovine S, Nicoli P, de Feudis P, Strepponi I, Roato I, Ferracini R, Bussolati B, Camussi G, Jones-Bolin S, Hunter K, Zhao H, Neri A, Palumbo A, Berkers C, Ovaa H, Bernareggi A, Inghirami G. Piva R, et al. Among authors: ovaa h. Blood. 2008 Mar 1;111(5):2765-75. doi: 10.1182/blood-2007-07-100651. Epub 2007 Dec 5. Blood. 2008. PMID: 18057228 Free article.
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Chauhan D, Catley L, Li G, Podar K, Hideshima T, Velankar M, Mitsiades C, Mitsiades N, Yasui H, Letai A, Ovaa H, Berkers C, Nicholson B, Chao TH, Neuteboom ST, Richardson P, Palladino MA, Anderson KC. Chauhan D, et al. Among authors: ovaa h. Cancer Cell. 2005 Nov;8(5):407-19. doi: 10.1016/j.ccr.2005.10.013. Cancer Cell. 2005. PMID: 16286248 Free article.
Fluorescence-based proteasome activity profiling.
de Jong A, Schuurman KG, Rodenko B, Ovaa H, Berkers CR. de Jong A, et al. Among authors: ovaa h. Methods Mol Biol. 2012;803:183-204. doi: 10.1007/978-1-61779-364-6_13. Methods Mol Biol. 2012. PMID: 22065226
Profiling proteasome activity in tissue with fluorescent probes.
Berkers CR, van Leeuwen FW, Groothuis TA, Peperzak V, van Tilburg EW, Borst J, Neefjes JJ, Ovaa H. Berkers CR, et al. Among authors: ovaa h. Mol Pharm. 2007 Sep-Oct;4(5):739-48. doi: 10.1021/mp0700256. Epub 2007 Aug 21. Mol Pharm. 2007. PMID: 17708652
Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.
Oerlemans R, Berkers CR, Assaraf YG, Scheffer GL, Peters GJ, Verbrugge SE, Cloos J, Slootstra J, Meloen RH, Shoemaker RH, Dijkmans BAC, Scheper RJ, Ovaa H, Jansen G. Oerlemans R, et al. Among authors: ovaa h. Invest New Drugs. 2018 Oct;36(5):797-809. doi: 10.1007/s10637-018-0569-x. Epub 2018 Feb 14. Invest New Drugs. 2018. PMID: 29442210 Free PMC article.
220 results